DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and IKZF4

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_001338018.1	Gene:	IKZF4 / 64375	HGNCID:	13179	Length:	585	Species:	Homo sapiens

Alignment Length:	707	Identity:	148/707 - (20%)
Similarity:	228/707 - (32%)	Gaps:	237/707 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 CKSSGHEEDAVDAEEPEDLELDDELL------SLSGDEDYDDEELQSL--DSFYSDMYSTHTSSS 179
            |:|||            |..|:.|.|      |:|..........:||  :|...:|||...||
Human    59 CESSG------------DSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESS- 110

  Fly   180 YSPSISDGTMTPNSHHLIGAPTAAGQEDHP--TEGKIN---GGADGEDLPKPKRLPHFHHHHHHH 239
                           .|:|......::|..  .|..::   |..||.. |:|
Human   111 ---------------RLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSG-PEP------------- 146

  Fly   240 YHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRL 304
             |....:::.|                                       |..:|..|.......
Human   147 -HSPGGIRLPN---------------------------------------GKLKCDVCGMVCIGP 171

  Fly   305 GYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKT 369
            ..|..|.:||....||.|..|...|..|.:..||.|||:.|:.:|||.|..|..|.|.|..|::|
Human   172 NVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRT 236

  Fly   370 HDIQ-----KPFQCSMCNRGYNTAAALTSHMQK-HKKNAAILAAGGNPNALNYSPRSTGSASASV 428
            |.:.     ||::|:.|.|.|...:.|..|.:: |                ||....:..|.|..
Human   237 HSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCH----------------NYLQSLSTEAQALA 285

  Fly   429 SSNG----SLQKRRYALALASDSSPSRMD-----FPKRSRSNHVGGTTTTATPTPLLRCSYCPKV 484
            ...|    .|:....::..:|...|:.:|     ..||.||            ||
Human   286 GQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRS------------TP---------- 328

  Fly   485 TEFSSLEQLNAHLQSV--------HEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMR 541
            .:|...:|:...|..:        :|:.........::.|.|..|:          ..|. :|:|
Human   329 QKFVGEKQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLA----------FVGA-EHLR 382

  Fly   542 STHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLSNNKRR 606
            ..   ||...|...|          .:|.::....:::|..|..|........:.|.||::.  .
Human   383 PL---RLPPTNCISE----------LTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADG--G 432

  Fly   607 PLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGMSLPEQSE 671
            ||...|:.  ||..|.|.|.    |.|... .|.||  || :..:| |:        :|||:...
Human   433 PLLYRPRG--PLTDPGASPS----NGCQDS-TDTES--NH-EDRVA-GV--------VSLPQGPP 478

  Fly   672 FE---RHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLL-------SEHVLTLL---------- 716
            .:   ..|||..             ..::||.:...|..|       |:.||.::
Human   479 PQPPPTIVVGRH-------------SPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAF 530

  Fly   717 KCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVH-VKTRHQLG 772
            ||..|..|....:...:|:.|...::.  ..|:.|....:...||..| |:..|::|
Human   531 KCEHCRILFLDHVMFTIHMGCHGFRDP--FECNICGYHSQDRYEFSSHIVRGEHKVG 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	11/24 (46%)
		COG5048	336..769	CDD:227381	104/476 (22%)
		zf-C2H2	348..370	CDD:278523	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	630..650	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	5/22 (23%)
		C2H2 Zn finger	689..707	CDD:275368	3/17 (18%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
IKZF4	NP_001338018.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..98		6/29 (21%)
		C2H2 Zn finger	161..181	CDD:275368	4/19 (21%)
		zf-H2C2_2	174..198	CDD:404364	9/23 (39%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		zf-H2C2_2	201..226	CDD:404364	11/24 (46%)
		SFP1	<211..271	CDD:227516	20/59 (34%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..271	CDD:275368	6/20 (30%)
		Interaction with FOXP3. /evidence=ECO:0000250\|UniProtKB:Q8C208	281..585		77/385 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..489		27/99 (27%)
		CTBP-binding motif PEDLA	425..429		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000