DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ikzf4

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_005162323.1	Gene:	ikzf4 / 566844	ZFINID:	ZDB-GENE-180319-1	Length:	572	Species:	Danio rerio

Alignment Length:	681	Identity:	155/681 - (22%)
Similarity:	219/681 - (32%)	Gaps:	225/681 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LELDD----ELLSLSGDEDYDDEELQSLDSFYSDM----YSTHTSSSYSPSISDGTMTPNS---- 193
            :..||    ..:|.|||...:.|       |::.:    .||..|...|||.|   ::.||
Zfish     2 MNADDCNGRSYMSGSGDSSTERE-------FFAGLRGPTVSTPNSQQSSPSRS---LSANSIKVE 56

  Fly   194 ----HHLIGAPTAAGQEDHPTEG-KINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLR 253
                ....|||....:.....|| |...|...||
Zfish    57 LYSDEEAGGAPLVERRVGEKDEGWKDEKGDLAED------------------------------- 90

  Fly   254 KINKEAKMGATAGGGATG-AASKFDKLTGEGIKSRG-----DGSYQCQFCEKTFPRLGYLKHHVQ 312
                   .|....||..| |.|...::......|.|     :|..:|..|.........|..|.:
Zfish    91 -------GGVEMVGGTRGQAGSGCGEMASSEPASPGPIRLPNGKLKCDICGMICIGPNVLMVHKR 148

  Fly   313 SH-----AEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDI 372
            ||     ....||:|..|...|..|.:..||.|||:.|:.:|||.|..|..|.|.|..|::||.:
Zfish   149 SHTVLVSVGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSV 213

  Fly   373 Q-----KPFQCSMCNRGYNTAAALTSHMQK-HKKNAAILAAGGNPNALNYSPRSTGSASASVS-- 429
            .     ||::||.|.|.|...:.|..|.:: |    :.|.:..:..|.|..| :.|..|.:|.
Zfish   214 SSPTVGKPYKCSYCGRSYKQQSTLEEHRERCH----SYLQSLDHQPAHNTQP-THGEESHNVEMI 273

  Fly   430 SNGSLQKRRYALALASDSSPSRMDF--------PKRSRSNHVGGTTTTATPTPLLRCSYCPKVTE 486
            |...:|           ||..:|.|        .||.||          ||...|.
Zfish   274 SEPLIQ-----------SSSEKMTFIDRLANSITKRKRS----------TPQKFLG--------- 308

  Fly   487 FSSLEQLNAHLQ-SVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMR-----STHM 545
                   ..|:: ::.|.|. .....|.:||:......|........:.|.|  ||     |..:
Zfish   309 -------EKHMRLNISEAPY-DLDPNPDKEGDLLLSHPEGDPAALAEMGGRF--MRGPRGGSNDV 363

  Fly   546 DRLSS----PNSYYEHFNRLATAGTFSPRLALDLPKIKP-----------DLGSPERESRPAEDD 595
            |...|    |:|        |....|:|.::...|.|.|           .:|...||:....:|
Zfish   364 DPSRSLRMPPHS--------ACLSEFTPVISSVYPHITPLGQRLNCAGGISMGLAGREAGEGHED 420

  Fly   596 LPT------DLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCN-------------------- 634
            ||:      ..||..:........|:......|||||     ..|
Zfish   421 LPSTRSRAASPSNGYQDSTDTESMAEEQCVITSAPPG-----NLNHRGRDRHSPSHAKEMDIEGD 480

  Fly   635 ------AGLPDFESFRNHLKSHIAEGMQLV-----------CPHCGMSLPEQSEFERHVVGHFLI 682
                  .|||...|.|:.|   ..|.||:|           |.||.:...:...|..|:..|..
Zfish   481 REKGVPGGLPTKASPRSPL---TREAMQVVDGEGRPVRSFRCEHCRIFFLDHVMFTIHMGCHGF- 541

  Fly   683 TGSEFNCSSSCGKSFAKSEDLQQHLLSEHVL 713
             ...|.| :.||.   :|:|  ::..|.|::
Zfish   542 -RQPFEC-NICGH---RSQD--RYEFSSHIV 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	11/24 (46%)
		COG5048	336..769	CDD:227381	108/458 (24%)
		zf-C2H2	348..370	CDD:278523	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	630..650	CDD:275368	7/45 (16%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	5/17 (29%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
ikzf4	XP_005162323.1	C2H2 Zn finger	130..150	CDD:275368	4/19 (21%)
		zf-H2C2_2	143..172	CDD:290200	9/28 (32%)
		COG5048	<146..337	CDD:227381	62/233 (27%)
		zf-C2H2	161..183	CDD:278523	8/21 (38%)
		C2H2 Zn finger	163..183	CDD:275368	7/19 (37%)
		zf-H2C2_2	175..200	CDD:290200	11/24 (46%)
		C2H2 Zn finger	191..211	CDD:275368	8/19 (42%)
		C2H2 Zn finger	224..245	CDD:275368	7/20 (35%)
		C2H2 Zn finger	519..539	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..564	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000