DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and si:ch211-216l23.1

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_005159186.1	Gene:	si:ch211-216l23.1 / 566696	ZFINID:	ZDB-GENE-060503-121	Length:	1372	Species:	Danio rerio

Alignment Length:	1519	Identity:	395/1519 - (26%)
Similarity:	577/1519 - (37%)	Gaps:	489/1519 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 AAPAAVAKEEEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEEDAVDAEEPEDLELDDELLS 149
            |.|.:|...||||  |.|.....|..|.:|||.:..   .|...|..||..:..:.:...||.:
Zfish     7 AKPRSVKAVEEAE--STECASGWDSSVQTDAAVSER---DSDRKESRAVGEDGEQSVTSHDERV- 65

  Fly   150 LSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKI 214
              |:||.||:.:.:.|:...|.          ..::|.|....:|      ..|..:|.|....:
Zfish    66 --GEEDLDDDSIFTCDNCQQDF----------ECLADLTEHRTNH------CPADGDDDPGLSWV 112

  Fly   215 NGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKL 279
            ......:|:..|.::                                   .|.|..      |..
Zfish   113 ASSPSSKDVASPSQM-----------------------------------LGDGCC------DMG 136

  Fly   280 TGEGIKSRGDG-SYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHT 343
            .|.|.:..|.| .|.||||:|:|.||.|||.|.|.|::.|||||.:||:|||||||||||.||||
Zfish   137 MGTGEEEGGSGLPYPCQFCDKSFSRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHVKLHT 201

  Fly   344 NERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAA- 407
            .::.|.|..||||||||||||||:|||...|||:||:|.||:::.::|.||||.|:||...||.
Zfish   202 GDKKYSCQECEAAFSRSDHLKIHLKTHSSSKPFKCSICKRGFSSTSSLQSHMQAHRKNKEHLAKK 266

  Fly   408 ------GGN---------------------------PNALNYSPRSTGSASAS-------VSSNG 432
                  |.:                           .:.|...|:.:..|...       .|..|
Zfish   267 DQGKRDGSSSDVTEQDQDLYMCDYCEETFSQTDELEKHVLTQHPQLSDRAELQCIHCPEIFSDEG 331

  Fly   433 SL--------QKRRYALALASDSSPS------RMDFPKR-SRSNH-------VGGTTTTATPTP- 474
            :|        ..:::...:.::..||      .:|..:: ..|||       :|...:.::.||
Zfish   332 TLLTHIDRTHANKKHKCPMCAEQFPSVEDVYCHLDSHRQPDSSNHSASPDPVLGSVASMSSATPD 396

  Fly   475 ---------------------------------------LLRCSYCPKVTEFSSLEQLNAHLQSV 500
                                                   ...|.||.| .:|:||..|..||:::
Zfish   397 SSASLERGSTPDSTLKPGQSRRKLAPSSDHDDGTWSGKVTYSCPYCSK-RDFNSLAVLEIHLKTI 460

  Fly   501 H-EQPQ----------------------TQAVKTPVQEGEGFQL---------SCEYCTMKFGNI 533
            | ::||                      .:|.::.......|.|         .|.||...|.:|
Zfish   461 HADKPQQSHTCQLCLETLPTLYNLNEHVRKAHRSSGNSASNFPLLQFSNVSAFHCNYCPDMFADI 525

  Fly   534 AGLFQHMRSTHMDRLS--------------------------SPNSYYEHFNR--LATAGTFSPR 570
            ..|.:|:|.:|.  ||                          :.:|..||..:  .::.|..:
Zfish   526 NSLQEHIRVSHC--LSGGVVAGSTTLEGNHAFFCNQCSMGFLTESSLTEHIQQTHCSSVGGVT-- 586

  Fly   571 LALDLPKIKPDLGSPERESRP------------------AEDDLPTDLSNNKRR-------PLTP 610
             .::.|.::|.....|..|.|                  .|:.....|:||||:       |.:.
Zfish   587 -KMESPVLQPSQSFMEVYSCPYCTNSPIFGSLLKLTKHIKENHKNIPLANNKRKVKVADLSPASS 650

  Fly   611 NPQAQTPL-------APPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLV-----CPHCG 663
            :.:..:|.       :.|:...|.:.||||:.....||.|:.|||||    ::|:     ||.|.
Zfish   651 DVEISSPKRHRVTGDSTPAVANGDYPCNQCDLRFSSFEGFQAHLKSH----LELLLRRQSCPQCN 711

  Fly   664 M-SLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCES 727
            . ....|....:|:..|:..|.:::.| .||.|.|:..:|||:|||..|...|..|:||.|:.:|
Zfish   712 KEDFDSQEALLQHLTIHYTTTSTQYVC-ESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDS 775

  Fly   728 RMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMF 792
            ::::|:|||..||.|.|:.||:||...||.:::..:|||..|.  |||   |::.||....:|:|
Zfish   776 KVSIQVHLAVKHSNEKKMYRCTACAWDFRKESDLQLHVKHSHL--GHP---ASTGAPGKARKCIF 835

  Fly   793 CRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNA 857
            |.....:|:|:..|:..|::::.|..|.:.||...||:||::.:|
Zfish   836 CGETFGTEVELQCHITTHSKKYNCRLCGKAFHAIVLLERHLREKH-------------------- 880

  Fly   858 LLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVD 922
                               .|.|             ||.|:|.||:|: |.|....:........
Zfish   881 -------------------CIFD-------------GGNGNGNGGSQN-GTPNGVTQSSKRSTAG 912

  Fly   923 TNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFS 987
            :.|...|......|:.|.||.      .|.|...||.|                ...:||...::
Zfish   913 STAAAEQADLQNMLLKGGSQE------TANSHEASGGE----------------EELDASEPMYA 955

  Fly   988 CGMCERQDLRSEAELHSHRKLAHNLKTGV---------------SLRCAYCAGNFKSRAELEQHM 1037
            |.:|... ...|:.|.:||...||::.|.               :.:|..|:..|.|...|.:|.
Zfish   956 CDICGAA-YTMESLLQNHRLRDHNIRPGEDDAGSRKKKADFIKGNHKCNVCSRTFFSENGLREHA 1019

  Fly  1038 KSCHNSTGKH-KCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSD 1101
            :: |....|| .|.||.|.|||...|.|||:.|||...:|.|..|..||:....|..|...|...
Zfish  1020 QT-HRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDL 1083

  Fly  1102 GASLP-LACICCRQTLHSEFELSLHAKFH-TKSSSSGGS--------------LQEP---VCALC 1147
            ..||. ..|:.|.||:.|..||.:|..|| .|.||||||              ||..   .||||
Zfish  1084 RNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLSSSGGSGGGGGSASSSPNGQLQAHKLYKCALC 1148

  Fly  1148 LEPLPDATE-------G-PAKLCDKCCRKHNLNGK-------------RG--------------- 1176
            |:...:..|       | |..||..|..: ..||:             :|
Zfish  1149 LKDFKNKQELVKIDVNGLPYGLCAGCMSR-GTNGQSPTVVVTPQEAGDKGTTGLRCSECAVKFET 1212

  Fly  1177 ----------KHSE--PATS--------LPAP-------------------------------PS 1190
                      .|:|  |.||        .|.|                               |:
Zfish  1213 LEDLESHIQVDHTEMSPETSGAKKVTDASPVPKKKTYQCIKCQMTFETEREIQIHVANHMIGEPA 1277

  Fly  1191 AF----VENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHG 1250
            ..    :.:.|.||..:.....||..||:||:|.|.... |.|.:|..||.....|..|: ..||
Zfish  1278 QLQEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFAVHG 1341

  Fly  1251 AHSRPYDCNLCPEKFFFRAELEHH 1274
            ...:.|||:.||:||||:.||::|
Zfish  1342 QEDKIYDCSQCPQKFFFQTELQNH 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	13/19 (68%)
		C2H2 Zn finger	322..342	CDD:275368	15/19 (79%)
		zf-H2C2_2	334..359	CDD:290200	16/24 (67%)
		COG5048	336..769	CDD:227381	161/633 (25%)
		zf-C2H2	348..370	CDD:278523	17/21 (81%)
		C2H2 Zn finger	350..370	CDD:275368	16/19 (84%)
		C2H2 Zn finger	378..398	CDD:275368	10/19 (53%)
		C2H2 Zn finger	630..650	CDD:275368	10/19 (53%)
		C2H2 Zn finger	659..679	CDD:275368	5/20 (25%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
si:ch211-216l23.1	XP_005159186.1	COG5048	<151..256	CDD:227381	68/104 (65%)
		C2H2 Zn finger	152..172	CDD:275368	13/19 (68%)
		C2H2 Zn finger	180..200	CDD:275368	15/19 (79%)
		COG5048	206..>539	CDD:227381	78/335 (23%)
		C2H2 Zn finger	208..228	CDD:275368	16/19 (84%)
		C2H2 Zn finger	236..256	CDD:275368	10/19 (53%)
		C2H2 Zn finger	288..307	CDD:275368	0/18 (0%)
		C2H2 Zn finger	439..460	CDD:275368	10/21 (48%)
		C2H2 Zn finger	471..492	CDD:275368	0/20 (0%)
		C2H2 Zn finger	515..534	CDD:275368	7/18 (39%)
		C2H2 Zn finger	677..697	CDD:275368	10/19 (53%)
		C2H2 Zn finger	707..728	CDD:275368	5/20 (25%)
		C2H2 Zn finger	738..755	CDD:275368	8/17 (47%)
		C2H2 Zn finger	766..783	CDD:275368	6/16 (38%)
		C2H2 Zn finger	796..817	CDD:275368	8/20 (40%)
		C2H2 Zn finger	833..853	CDD:275368	6/19 (32%)
		C2H2 Zn finger	859..877	CDD:275368	8/17 (47%)
		C2H2 Zn finger	956..977	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1002..1022	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1031..1051	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1288..1308	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1319..1340	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1349..1365	CDD:275368	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10949
eggNOG	1	0.900	-	-		E33208_3BE22
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222002at33208
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	1	1.000	-	-		otm25427
orthoMCL	1	0.900	-	-		OOG6_106906
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4838
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760