DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and rest

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_001340795.1	Gene:	rest / 564772	ZFINID:	ZDB-GENE-080415-1	Length:	854	Species:	Danio rerio

Alignment Length:	1096	Identity:	210/1096 - (19%)
Similarity:	327/1096 - (29%)	Gaps:	395/1096 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 QQSWPTADEPAAPAAVAKEEEAEEGSEELQHPRDEVVASDAA--ANANGHCKSSGHEEDAVDAEE 137
            |..:|||.....|              :|.|  |||.|....  ||.....::|..|   ...|.
Zfish     3 QPVFPTASGIFLP--------------DLHH--DEVSAPQLVMLANVVVSAEASASE---YSTEG 48

  Fly   138 PEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAP-- 200
            .:.:||.....|...|.:.||:.:                ..||...|:...|..:.|:...|
Zfish    49 KQMMELQTVACSSYSDSEEDDDAV----------------VRYSMDTSEDLYTQQASHIQPEPVL 97

  Fly   201 -----TAAGQEDHPTEGKINGGADGE--------DLPKPKRLPHFHHHHHHHYHHQQALKI---- 248
                 ...|:..:.||...|..:..:        :..|.|:.|.|.....:...::|...:
Zfish    98 EEIEIVRVGRPPNQTESTENAASAEQKRTTLAILESSKKKKKPFFCKPCQYQGENEQEFIVHIRT 162

  Fly   249 --ANKLRKIN---KEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPR----L 304
              |.|:..:|   .:..:.|.||       .:......|..:|...|..:|:.|.....|    :
Zfish   163 HGAKKMLVVNGGDSDEDLSADAG-------PQTSVPNAESAESNSKGVIRCERCGYNTNRFDHYM 220

  Fly   305 GYLKHHVQSHAEHLPFKCEYC-------------------SKLF---------KHKRSRDRHKKL 341
            .:||||.:...:...|||..|                   ||||         ..|.:..:|.:.
Zfish   221 AHLKHHTKEGEDQRVFKCTICAYTTISQYHWKKHLRNHFPSKLFTCSQCSYFSDRKNNYIQHIRT 285

  Fly   342 HTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILA 406
            ||.||.::|.:||.:.|:..||..||:||..::||:|..|                     :.||
Zfish   286 HTGERPFQCIYCEYSSSQKTHLTRHMRTHSGERPFKCDNC---------------------SYLA 329

  Fly   407 AGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTAT 471
            |                                          ::.:..:.:|..|.|
Zfish   330 A------------------------------------------NQHEVTRHARQVHNG------- 345

  Fly   472 PTPLLRCSYCPKVTEFSSLEQLN--AHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIA 534
            |.| |.|.||    ::.:.::.|  .|:: :|..|:              |..|..|........
Zfish   346 PKP-LSCPYC----QYKTADRSNFKKHVE-LHVNPR--------------QFLCPVCKYAASKKC 390

  Fly   535 GLFQHMRSTH-------MD----RL---------SSPNSYYEH----FNRLATAGTFSPRLALDL 575
            .|..|::|.|       ||    ||         :|||.....    ...|..||..:  |::..
Zfish   391 NLQYHIKSRHPGCKDISMDVSKVRLRVKRSDGDDASPNKLTAEQAKIMEELEDAGPIN--LSIKK 453

  Fly   576 PK-----IKPDLGSPERESRPAEDDLPTD---LSNNKRRPLTP---------------------- 610
            |.     ::.:..|.:.....|....|.:   ||.|:.:..|.
Zfish   454 PSKLNAVVETEKSSKKNMDGKANQPQPNEKKSLSKNEPKEKTAKKLKGKTAVKDTEETQTEDTRV 518

  Fly   611 NPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGMS--LPEQSEFE 673
            |.:.:|..|..||...:             :|.:...|......:|.....|..:  .|:|:|.:
Zfish   519 NNKKETKKAEKSAEKAL-------------KSRQKKEKPVKDSSVQQQSDDCEQTQHTPQQNETQ 570

  Fly   674 RHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACA 738
            .:.......:.:|.:.:..|||...|....:|      ..||   .:|.|             ..
Zfish   571 ENRPEKENRSLTEIDNAKDCGKVQTKKPCKKQ------TKTL---KVCGE-------------TQ 613

  Fly   739 HSQETKLLRCSACLELFRSDAEFHVHVK-TRHQLGGHPTLGATSSA-PTNPLQCMFCRAVCSSEL 801
            :.:|.:::|..|......:.||....:| |:.:..|.||   ||.| .|||       .|..||
Zfish   614 NVEEEEIMRQKAGKRKADNPAEPKQRIKRTKKKDSGKPT---TSEANQTNP-------EVMESE- 667

  Fly   802 EMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGV----KDKEANS----PNMGSLYVNAL 858
                  ::.|.....|.           |...:||:..|    .|.|..|    |...:..|..:
Zfish   668 ------SSEANNASKPD-----------DSIDESQNPPVAESRPDVEPQSVPDCPIEKAPAVEEV 715

  Fly   859 LPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAP--PSANKFYSPLQV 921
            ..||....:.||.                                   .||  .|.|:..||...
Zfish   716 QRPLEVEISTAAP-----------------------------------DAPEVDSGNEMPSPTDS 745

  Fly   922 D-----TNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNA 981
            |     |..|..|..|..|    .....:.........|.|.:||..:|...|.....|..|
Zfish   746 DGAPGFTPTLPLQHKPADA----EDDEGIHSNDGGSDISDSASEGSYDSGLMAGAEKLPETP--- 803

  Fly   982 STATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHM 1037
                     .|.:| .|.|.|.||             .|.:|..:|....:..:|:
Zfish   804 ---------TEERD-ASAARLLSH-------------TCIFCDRSFALEMDYRKHL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/23 (30%)
		C2H2 Zn finger	322..342	CDD:275368	8/47 (17%)
		zf-H2C2_2	334..359	CDD:290200	8/24 (33%)
		COG5048	336..769	CDD:227381	90/491 (18%)
		zf-C2H2	348..370	CDD:278523	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	2/19 (11%)
		C2H2 Zn finger	630..650	CDD:275368	2/19 (11%)
		C2H2 Zn finger	659..679	CDD:275368	4/21 (19%)
		C2H2 Zn finger	689..707	CDD:275368	5/17 (29%)
		C2H2 Zn finger	1020..1041	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
rest	NP_001340795.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..199		5/33 (15%)
		C2H2 Zn finger	238..258	CDD:275368	2/19 (11%)
		C2H2 Zn finger	266..286	CDD:275368	2/19 (11%)
		zf-H2C2_2	278..303	CDD:316026	8/24 (33%)
		zf-C2H2_2	293..>367	CDD:315435	27/148 (18%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-H2C2_2	306..327	CDD:316026	10/41 (24%)
		C2H2 Zn finger	326..343	CDD:275370	4/58 (7%)
		C2H2 Zn finger	351..371	CDD:275368	5/24 (21%)
		C2H2 Zn finger	379..397	CDD:275368	4/17 (24%)
		MIP-T3	453..>769	CDD:313469	76/417 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000