DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zxdc

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_002729441.4	Gene:	Zxdc / 362399	RGDID:	1561296	Length:	878	Species:	Rattus norvegicus

Alignment Length:	1199	Identity:	213/1199 - (17%)
Similarity:	311/1199 - (25%)	Gaps:	553/1199 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 APEGGG-GERPQLVPNESQQQSWPTADEPAAPAAVAKEEEAEEGSEE----LQHPRDEVVASDAA 116
            :||.|| |.|.:..|..|          |..|         |:|.:.    |:.||
  Rat    68 SPEDGGPGPRQEEAPGPS----------PPPP---------EDGGDSFVVLLEVPR--------- 104

  Fly   117 ANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYS 181
                           |.|..|.|:.|.|                        |....|....:.:
  Rat   105 ---------------AADTHEQEETEPD------------------------SGASPTEQVPAAA 130

  Fly   182 PSIS-DGTMTPNSHHLI-----------GAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHH 234
            |..: .||:|.::..|:           .||..|.|..||
  Rat   131 PGAALAGTVTIHNQDLLVRFDRGVFTLAAAPAPATQGLHP------------------------- 170

  Fly   235 HHHHHYHHQQALKIANKLRKINKEAKMGATAGG--GATGAASKFDKLTGEGIKSRGDGSYQC--Q 295
                                        ||..|  .::.|||:    .|....|.|..:|:|  .
  Rat   171 ----------------------------ATTPGLEPSSAAASR----RGPVAASAGSPAYRCPEP 203

  Fly   296 FCEKTFPRLGYLKHHVQSHAE---HLPFKC--EYCSKLFKHKRSRDRHKKLHTNERNYKCP--HC 353
            .|..:|.:...||.|:.:|..   ..||||  :.|...|.......||.:.|...|.:.||  .|
  Rat   204 QCALSFAKKHQLKVHLLTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDKLRPFSCPVGGC 268

  Fly   354 EAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSP 418
            ...|:...:||.|||.|:.:..|:|.:|...:.|.|.|.||.:.|                 :.|
  Rat   269 GKKFTTVYNLKAHMKGHEQESLFKCEVCAERFPTHAKLNSHQRSH-----------------FEP 316

  Fly   419 RSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPK 483
                                        ..|.:.|||.
  Rat   317 ----------------------------ERPYKCDFPG--------------------------- 326

  Fly   484 VTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRL 548
                                                      |...|..::.||.|.|:
  Rat   327 ------------------------------------------CEKTFITVSALFSHNRA------ 343

  Fly   549 SSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQ 613
                    ||.                          |:|
  Rat   344 --------HFR--------------------------EQE------------------------- 349

  Fly   614 AQTPLAPPSAPPGVFFCN--QCNAGLPDFESFRNHLKSHIAEGMQLVC--PHCGMSLPEQSEFER 674
                         :|.|:  .||.........:.||:||..| ...:|  ..||.:....|:..|
  Rat   350 -------------LFSCSFPGCNKQYDKACRLKIHLRSHTGE-RPFICDSDSCGWTFTSMSKLLR 400

  Fly   675 HVVGHFLITGSEFNCS-SSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACA 738
            |...|  .....|.|. ..|||||.::|.|:.|.::                        ||.
  Rat   401 HKRKH--DDDRRFTCPVEGCGKSFTRAEHLKGHSIT------------------------HLG-- 437

  Fly   739 HSQETKLLRC--SACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSEL 801
                ||...|  ..|...|.:.:..::|.|...|..|.|
  Rat   438 ----TKPFECPVEGCCARFSARSSLYIHSKKHLQDVGTP-------------------------- 472

  Fly   802 EMHFHLAAHARQFRCP--SCPETFHVEFLLDRHMQSQHGGVKD--------------KEANSPNM 850
                       :.|||  ||...|..:..:..||..||...:|              .|.:||..
  Rat   473 -----------KSRCPVSSCNRLFTSKHSMKAHMVRQHSRRQDLVPQLEAPSSLTPSSELSSPGQ 526

  Fly   851 GSLY---VNALLPPLAAAAAAAAATNN---NSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGG-- 907
            ..|.   :.||.....|.::::.|.::   ||.|:..:|         :..:.|.||...:..
  Rat   527 SELTNIDLAALFSDTPANSSSSTAGSDEALNSGILTIDV---------TSVSSSLGGNLPTNNNS 582

  Fly   908 --------------APPSANKFYSPLQVDTNALKAQTSPHPA------------LMYGLSQRYLM 946
                          .|||.:   |||.:.|.|...|.....|            .:..|..|.|.
  Rat   583 LGPMDPLVLVAHSDMPPSLD---SPLVLGTPATVLQPGSFSADDSQAMSTGAVGCLVALPMRNLS 644

  Fly   947 EMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHN 1011
            :  .:.:.:||.|.....:.|.:...|    ...||.......:...|||....::...:|.:|.
  Rat   645 Q--DSPALTPSNNLTALGTTPTSSDTT----QETASVPDLLVPIKVEQDLSPVPDVVQGQKESHG 703

  Fly  1012 ---------------------------LKTGVSLRCAYCAGNF------KSRAELEQHMKSCHNS 1043
                                       |::|.|.|..|.|...      |.....|....|.|..
  Rat   704 PSVLSSSAERLGAQKDSELSAGTGSLYLESGGSARTDYRAIQLVKKKKQKGTGSDEGASDSAHRK 768

  Fly  1044 ------------TGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQ-PLEDVAAFRAHL 1095
                        :|:|.|...:.:.||.::         .|......:.|.| |:         |
  Rat   769 IKGSTVSLPHVHSGQHSCFCGNPMAPSGSL---------PVPAPAAATQCVQIPV---------L 815

  Fly  1096 SEHGSDGASLPLACICCRQTLHSEFELSL 1124
            .:..|....||||....|...|..|.:.|
  Rat   816 QDDPSGEGGLPLALSPQRSAFHPYFTVDL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	6/21 (29%)
		C2H2 Zn finger	322..342	CDD:275368	5/21 (24%)
		zf-H2C2_2	334..359	CDD:290200	8/26 (31%)
		COG5048	336..769	CDD:227381	73/441 (17%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	5/21 (24%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368	5/26 (19%)
		C2H2 Zn finger	1049..1069	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Zxdc	XP_002729441.4	COG5048	<198..385	CDD:227381	62/379 (16%)
		C2H2 Zn finger	200..222	CDD:275368	6/21 (29%)
		C2H2 Zn finger	233..255	CDD:275368	5/21 (24%)
		zf-C2H2_8	263..340	CDD:406359	28/190 (15%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	322..344	CDD:275368	9/104 (9%)
		C2H2 Zn finger	356..375	CDD:275368	4/18 (22%)
		C2H2 Zn finger	383..405	CDD:275368	6/21 (29%)
		zf-H2C2_2	398..424	CDD:404364	10/27 (37%)
		C2H2 Zn finger	413..435	CDD:275368	9/45 (20%)
		COG5048	414..>692	CDD:227381	69/362 (19%)
		C2H2 Zn finger	443..465	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46179
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100