DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oaz and CG17612

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	150/863 - (17%)
Similarity:	242/863 - (28%)	Gaps:	376/863 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GERPQLVPNESQQQSWPTADEPAAP--------AAVAKEEEA---EEGSEELQHPRDEVVASDAA 116
            |.||:...|:..........|...|        ..|.|||:|   ::..||.....:|::.:...
  Fly    42 GPRPETQINDKVHLEMSINGEDGLPEHPLYPEVQLVVKEEDALIKKKVIEENHIHNEEIIGASNI 106

  Fly   117 ANANGHCKSSGHEEDAVDAEE--PEDLELDD----------------ELLSLSGDEDYDDEELQS 163
            .:...| ::.....|.:..::  .|::.|:|                |.|.:..:|..:.|:||.
  Fly   107 VDVEVH-ENHRANNDVILIQDSFAEEVILEDHPANNDVIIIQDSVAEEELPVIKEEAIEGEDLQG 170

  Fly   164 LDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKR 228
                   .|...|.....|:|.            .......|.|:.|    |...|.
  Fly   171 -------EYFIITECLEEPAIG------------SCRVCLEQSDNLT----NIFDDA-------- 204

  Fly   229 LPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGD--GS 291
                         ||..:.||..|                        .:.||..:: :||  ..
  Fly   205 -------------HQYGIPIATIL------------------------SQYTGMPVE-KGDSFSE 231

  Fly   292 YQCQFC----EKTFPRLGYLKHHVQSH---------AEHLPFKCEYCSKLFKHKRSRDRHKKLH- 342
            |.|..|    :..|..|...::.:|.:         .:.:|.|                :|.:.
  Fly   232 YICVTCLDVVKNAFDDLESKENTIQMYRQPKEEIIDIDSIPVK----------------NKPVDY 280

  Fly   343 --TNERNYKCPHCEAAFSRSDHLKIHMKTHD----IQKP-FQCSMCNRGYNTAAALTSHMQKHKK 400
              |.:..::||.|...|..:..|:.|::||:    .:.| .:|.||...|.....|.:||..|:
  Fly   281 EVTGKPPHRCPQCPKIFLLAAKLQAHIRTHNETRTTEPPRLKCPMCPSIYMKRGCLEAHMWIHR- 344

  Fly   401 NAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGG 465
                                                       |||...|.::
  Fly   345 -------------------------------------------ASDERESELE------------ 354

  Fly   466 TTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKF 530
                    |..||.:|||:..:||.  |..|:|
  Fly   355 --------PPYRCPHCPKLFLYSSF--LEIHIQ-------------------------------- 377

  Fly   531 GNIAGLFQHMRSTHMD---RLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPA 592
                        ||.|   |||..:|:.
  Fly   378 ------------THEDVSQRLSRKSSHK------------------------------------- 393

  Fly   593 EDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQL 657
                                                 |.||.....|..|.::|:|.|..| ...
  Fly   394 -------------------------------------CAQCADVFSDVSSLKDHVKIHAGE-RTF 420

  Fly   658 VCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLT-LLKCSLC 721
            .||.|.||..|:|..:.|...|     :.|.| ..|.|.|.....|..|....|... ..||..|
  Fly   421 KCPLCLMSFQEESNLKSHDCAH-----TRFKC-HKCSKFFESQNYLDFHFKKSHTTKGPFKCIKC 479

  Fly   722 SELCESRMAMQLHLA---CAHSQETK----LLRCSACLELFRSDAEFHVH------VKT---RHQ 770
            .:..:.|..::.|::   |.....:|    :..|..|.:.|..:..:.:|      |||   ||
  Fly   480 QQTFQKRNGLKEHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMHHATHKKVKTVIERH- 543

  Fly   771 LGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQS 835
                              .|..|:....::..:..|:.:|.   ||..|..:|..::||::|..|
  Fly   544 ------------------NCTQCKKSYQNKKLLTKHILSHN---RCVHCSMSFTSKYLLEQHTCS 587

  Fly   836 QH---GGVKDKEANSPNM 850
            |.   .|.:.::  :||:
  Fly   588 QSYQLNGSRGRK--NPNL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	5/23 (22%)
		C2H2 Zn finger	322..342	CDD:275368	1/19 (5%)
		zf-H2C2_2	334..359	CDD:290200	6/27 (22%)
		COG5048	336..769	CDD:227381	81/460 (18%)
		zf-C2H2	348..370	CDD:278523	6/21 (29%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	8/19 (42%)
		C2H2 Zn finger	689..707	CDD:275368	5/17 (29%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	17/108 (16%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275370	7/19 (37%)
		zf-C2H2_8	356..438	CDD:292531	33/202 (16%)
		C2H2 Zn finger	359..379	CDD:275368	9/65 (14%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..438	CDD:275368	7/15 (47%)
		C2H2 Zn finger	447..463	CDD:275368	5/16 (31%)
		C2H2 Zn finger	476..505	CDD:275368	5/28 (18%)
		C2H2 Zn finger	513..533	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..565	CDD:275368	3/19 (16%)
		C2H2 Zn finger	568..584	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930