DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ikzf1

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_005156674.1	Gene:	ikzf1 / 30177	ZFINID:	ZDB-GENE-980526-304	Length:	641	Species:	Danio rerio

Alignment Length:	732	Identity:	152/732 - (20%)
Similarity:	243/732 - (33%)	Gaps:	249/732 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 EEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDD 158
            |||:|.|        ::...|:..|||    ..|.::|.. ...||||.....|
Zfish   108 EEAQEMS--------QITGRDSPMNAN----EGGEDQDEA-MPVPEDLSASTGL----------- 148

  Fly   159 EELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGAD---G 220
                        .::..|....:.:|.              ..|...|::....::||.|:   .
Zfish   149 ------------QHNNRTDKPLACNIK--------------VEARSDEENGLSCEMNGEAEECAA 187

  Fly   221 EDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIK 285
            |||    |:                  :.....|:|     |:.||..:..||..    |..||:
Zfish   188 EDL----RI------------------LDGSGAKVN-----GSHAGPDSKPAAYP----TAGGIR 221

  Fly   286 SRGDGSYQCQFCEKTFPRLGYLKHHVQSHAE-----------HLPFKCEYCSKLFKHKRSRDRHK 339
             ..:|..:|..|.........|..|.:||.|           ..||:|..|...|..|.:..||.
Zfish   222 -LPNGKLKCDICGIVCIGPNVLMVHKRSHTEERKSVLEQQKGERPFQCNQCGASFTQKGNLLRHI 285

  Fly   340 KLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQK-HKKNAA 403
            |||:.|:.:||..|..|..|.|.|..|::||.:.||.:|:.|.|.|...::|..|.:: |.
Zfish   286 KLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCAYCGRSYKQRSSLEEHKERCHN---- 346

  Fly   404 ILAAGGNPNALNYSPRSTGSASA-------------------SVSSNGSLQKRRYA-------LA 442
            .|...|..|:: |:.:...|.:.                   :|:...|...:|:.       |:
Zfish   347 YLQCMGLQNSI-YTVKEENSQNEQREDMPASERALVLDRIANNVAKRKSSMPQRFVGENRLSELS 410

  Fly   443 LASDS----SPSRMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQ 503
            ..|.|    .|..:|....|..:::|..:.    .||::       |...|.:.:.:.|.::|
Zfish   411 FESGSGELMQPHVIDQAINSAISYLGAESL----RPLVQ-------TSPGSADMVVSPLYNLH-- 462

  Fly   504 PQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFS 568
                  |:...||.|                             :|:.:|..||...|:.:.:.|
Zfish   463 ------KSQTAEGNG-----------------------------VSAKDSAAEHLLLLSKSKSAS 492

  Fly   569 PRLALDLPKIKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQC 633
                     :..| |||   |...:|...|: |||:.|....:..|.|
Zfish   493 ---------VDKD-GSP---SPSGQDSTDTE-SNNEERSAGVSGTAAT----------------- 526

  Fly   634 NAGLPDFESFRNHLKSHIAEGMQLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGK--S 696
             .||       .:|.:|:|.||:      ...||...| |:|         .:|....:.|.  |
Zfish   527 -GGL-------IYLTNHMAPGMR------NGGLPGVKE-EQH---------RQFEALRAAGMDLS 567

  Fly   697 FAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEF 761
            .|.||..:........|...:|..|..|....:...:|:.|...::.  ..|:.|  .:||
Zfish   568 IASSEGFKVLSGDGEELRAYRCIHCRVLFLDHVMYTIHMGCHGFRDP--FECNLC--GYRS---- 624

  Fly   762 HVHVKTRHQLGGHPTLG 778
                :.|::...|.|.|
Zfish   625 ----QDRYEFSSHITRG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	10/24 (42%)
		COG5048	336..769	CDD:227381	97/465 (21%)
		zf-C2H2	348..370	CDD:278523	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	630..650	CDD:275368	3/19 (16%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
ikzf1	XP_005156674.1	C2H2 Zn finger	229..249	CDD:275368	4/19 (21%)
		COG5048	<236..>339	CDD:227381	34/102 (33%)
		zf-H2C2_2	242..277	CDD:290200	10/34 (29%)
		zf-C2H2	266..288	CDD:278523	8/21 (38%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..305	CDD:290200	10/24 (42%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	312..333	CDD:290200	9/20 (45%)
		C2H2 Zn finger	324..345	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000