DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ZNF521

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_056276.1	Gene:	ZNF521 / 25925	HGNCID:	24605	Length:	1311	Species:	Homo sapiens

Alignment Length:	1511	Identity:	370/1511 - (24%)
Similarity:	533/1511 - (35%)	Gaps:	580/1511 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 HCKSSGHEED--AVDAEE-PEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPS 183
            :||.....||  |:|.:: |||            .|:.:||.:.|.||          ......|
Human    16 NCKLEDKTEDGEALDCKKRPED------------GEELEDEAVHSCDS----------CLQVFES 58

  Fly   184 ISDGTMTPNSHHLIGAPTAAGQEDHPTEGKIN-----GGADGEDLPKPKRLPHFHHHHHHHYHHQ 243
            :||                      .||.|||     .|.|.||.|
Human    59 LSD----------------------ITEHKINQCQLTDGVDVEDDP------------------- 82

  Fly   244 QALKIANKLRKINKEAKMGATAGGGATGAASKFDKLT---GEGI----KSRGDG-SYQCQFCEKT 300
                                |....|:..:|| |:.:   |||.    :..|.| .|.||||:|:
Human    83 --------------------TCSWPASSPSSK-DQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKS 126

  Fly   301 FPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKI 365
            |.||.|||||.|||::.|||||.|||:|||||||||||.||||.::.|.|..|:|||||||||||
Human   127 FSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKI 191

  Fly   366 HMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSS 430
            |:|||...||::|::|.||:.::::|..|||.|::|                  ..||.|.|...
Human   192 HLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERN------------------KDGSQSGSRME 238

  Fly   431 NGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTATPT---PLLRCSYCPKV-------- 484
            :..::..:     .........|||: ....|:.......:|.   ..|:|.||.::
Human   239 DWKMKDTQ-----KCSQCEEGFDFPE-DLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLM 297

  Fly   485 -------------------TEFSSLEQLNAHLQSVHEQPQT------------------------ 506
                               ..|.::|:|.:|:.| |:||::
Human   298 NHMEQVHSGEKKNSCSICSESFHTVEELYSHMDS-HQQPESCNHSNSPSLVTVGYTSVSSTTPDS 361

  Fly   507 ------------------------QAVKTPVQEGEGFQ-----LSCEYCTMK-FGNIAGLFQHMR 541
                                    .|.:||...|...:     .||.||..: |.::|.|..|::
Human   362 NLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLK 426

  Fly   542 STHMDR-------------LSSPNSYYEHFNRLATAG----------------TFSPRLALDLPK 577
            :.|:|:             |.|..:..||..::..|.                .|...:..||..
Human   427 TMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNT 491

  Fly   578 IKPDLGSPERESRPAEDD-------------------------LPTDLS---------------- 601
            ::..:......:.||..|                         :..|||
Human   492 LQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPV 556

  Fly   602 ---------------------------NNKRRPLTPN-------PQAQTPLAP------------ 620
                                       |:|..||..|       .:|.:||:|
Human   557 VEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQ 621

  Fly   621 -----PSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGM-QLVCPHCGMSLPEQSEFERHVVGH 679
                 |:.|.|.:.||||.|.....:||:.|||:|:...: :|.||.|....|.|....:||..|
Human   622 AVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIH 686

  Fly   680 FLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETK 744
            |:||.:.:.| .||.|.|...:|||:|||..|.....:|:||.|:.:|::::|||||..||.|.|
Human   687 FMITSTYYIC-ESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKK 750

  Fly   745 LLRCSACLELFRSDAEFHVHVKTRH---QLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFH 806
            :.||::|...||::.:..:|||..|   |...|              :|:||.....:|:|:..|
Human   751 VYRCTSCNWDFRNETDLQLHVKHNHLENQGKVH--------------KCIFCGESFGTEVELQCH 801

  Fly   807 LAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAA 871
            :..|::::.|..|.:.||...||::|::.:|...   |..:||.|
Human   802 ITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVF---ETKTPNCG-------------------- 843

  Fly   872 TNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPAL 936
            ||                 |||.                         ||....::.||
Human   844 TN-----------------GASE-------------------------QVQKEEVELQT------ 860

  Fly   937 MYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAE 1001
                   .|.....:.::.....|.|..|:|                 .:.|.:|... ...|..
Human   861 -------LLTNSQESHNSHDGSEEDVDTSEP-----------------MYGCDICGAA-YTMETL 900

  Fly  1002 LHSHRKLAHNLKTGVS-------------LRCAYCAGNFKSRAELEQHMKSCHNSTGKH-KCLIC 1052
            |.:|:...||::.|.|             .:|..|:..|.|...|.:||:: |....|| .|.||
Human   901 LQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQT-HLGPVKHYMCPIC 964

  Fly  1053 DEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLP-LACICCRQTL 1116
            .|.|||...|.|||:.|||...:|.|..|..||:....|..|...|.....||. ..|:.|.||:
Human   965 GERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTV 1029

  Fly  1117 HSEFELSLHAKFHTKSSSSGGSLQEP----------VCALCLEP--------------LP----- 1152
            .|..||.:|..||.:.:.:|.::|..          .||.||:.              ||
Human  1030 TSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCA 1094

  Fly  1153 ------------------------------DATEGPAKL------CDKCCRKHNLNGKRGKHSEP 1181
                                          .|.||..|:      |..|..|.....:...|.:.
Human  1095 GCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQT 1159

  Fly  1182 ----------ATSLPAP---------PSAFVENR------------------------------- 1196
                      :|.|..|         ||...|.:
Human  1160 IHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN 1224

  Fly  1197 --CNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHGAHSRPYDC 1258
              |.||........|||.||:||:|.|.... |.|.:|..||.....|..|: ..||...:.|||
Human  1225 HECKLCSQTFDSPAKLQCHLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDC 1288

  Fly  1259 NLCPEKFFFRAELEHH 1274
            ..||:||||:.||::|
Human  1289 TQCPQKFFFQTELQNH 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	322..342	CDD:275368	16/19 (84%)
		zf-H2C2_2	334..359	CDD:290200	15/24 (63%)
		COG5048	336..769	CDD:227381	155/638 (24%)
		zf-C2H2	348..370	CDD:278523	16/21 (76%)
		C2H2 Zn finger	350..370	CDD:275368	15/19 (79%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	630..650	CDD:275368	10/19 (53%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
ZNF521	NP_056276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		9/66 (14%)
		C2H2 Zn finger	120..140	CDD:275368	14/19 (74%)
		COG5048	128..>216	CDD:227381	57/87 (66%)
		C2H2 Zn finger	148..168	CDD:275368	16/19 (84%)
		C2H2 Zn finger	176..196	CDD:275368	15/19 (79%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	248..265	CDD:275368	3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..397		4/47 (9%)
		C2H2 Zn finger	407..428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	439..460	CDD:275368	4/20 (20%)
		C2H2 Zn finger	479..498	CDD:275368	3/18 (17%)
		C2H2 Zn finger	636..656	CDD:275368	10/19 (53%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	696..713	CDD:275368	8/17 (47%)
		C2H2 Zn finger	724..745	CDD:275368	10/20 (50%)
		C2H2 Zn finger	754..774	CDD:275368	7/19 (37%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..882		2/18 (11%)
		C2H2 Zn finger	888..909	CDD:275368	5/21 (24%)
		C2H2 Zn finger	932..952	CDD:275368	7/20 (35%)
		C2H2 Zn finger	961..981	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1188		4/19 (21%)
		C2H2 Zn finger	1227..1247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1258..1279	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1288..1307	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10792
eggNOG	1	0.900	-	-		E33208_3BE22
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3168
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222002at33208
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106906
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730