DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Ikzf4

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_035902.2	Gene:	Ikzf4 / 22781	MGIID:	1343139	Length:	586	Species:	Mus musculus

Alignment Length:	699	Identity:	145/699 - (20%)
Similarity:	207/699 - (29%)	Gaps:	229/699 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PAAP------AAVAKEEEAEEGSEELQHPRDEVVASD--AAANANGH-------CKSSGHEEDAV 133
            ||.|      ..|.......:|.:.|:.......|.|  ..|..:.|       |:|||
Mouse     5 PALPRRFQGGGRVRTPGSHRQGKDNLERELSGGCAPDFLPQAQDSNHFIMESLFCESSG------ 63

  Fly   134 DAEEPEDLELDDELL------SLSGDEDYDDEELQSL--DSFYSDMYSTHTSSSYSPSISDGTMT 190
                  |..|:.|.|      |:|..........:||  :|...:|||...||.        .:.
Mouse    64 ------DSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSR--------LLG 114

  Fly   191 PNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKI 255
            |: ..|:....:...||..:|..  |..||.. |:|              |....:::.|
Mouse   115 PD-ERLLDKDDSVIVEDSLSEPL--GYCDGSG-PEP--------------HSPGGIRLPN----- 156

  Fly   256 NKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPF 320
                                              |..:|..|.........|..|.:||....||
Mouse   157 ----------------------------------GKLKCDVCGMVCIGPNVLMVHKRSHTGERPF 187

  Fly   321 KCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQ-----KPFQCSM 380
            .|..|...|..|.:..||.|||:.|:.:|||.|..|..|.|.|..|::||.:.     ||::|:.
Mouse   188 HCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNY 252

  Fly   381 CNRGYNTAAALTSH-------MQKHKKNAAILAA--GGNPNALNYSPRSTGSASASVSS-----N 431
            |.|.|...:.|..|       :|....:|..|..  |.....|...|.|....|....:     .
Mouse   253 CGRSYKQQSTLEEHKERCHNYLQSLSTDAQALTGQPGDEIRDLEMVPDSMLHPSTERPTFIDRLA 317

  Fly   432 GSLQKRRYALALASDSSPSRMDFPKRSRSN----------------------HVG-----GTTTT 469
            .||.||:       .|:|.:....|:.|.:                      |.|     |.:..
Mouse   318 NSLTKRK-------RSTPQKFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGFGGSLA 375

  Fly   470 ATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQ-----------TQAVKTPVQEGEGFQL-- 521
            ...|..||....|..   :.:.:|...:.||:.|.|           .:|.:.|...|:|..|
Mouse   376 FVGTEHLRPLRLPPT---NCISELTPVISSVYTQMQPIPSRLELPGSREAGEGPEDLGDGGPLLY 437

  Fly   522 ---------------SCEYCTMKFGNIAGLFQHMRSTHMDRL----SSPNSYYEHFNRLATAGTF 567
                           .|:..|           ...|.|.||:    |.|.............|..
Mouse   438 RARGSLTDPGASPSNGCQDST-----------DTESNHEDRIGGVVSLPQGPPPQPPPTIVVGRH 491

  Fly   568 SPRLALDLPKIKPDL--GSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFC 630
            ||..|.:.||.:..|  |:|                       .|:.:....:.....|...|.|
Mouse   492 SPAYAKEDPKPQEGLLRGTP-----------------------GPSKEVLRVVGESGEPVKAFKC 533

  Fly   631 NQCNAGLPDFESFRNHLKSHIAEGMQ--LVCPHCGMSLPEQSEFERHVV 677
            ..|.....|...|..|:..|   |.:  ..|..||....::.||..|:|
Mouse   534 EHCRILFLDHVMFTIHMGCH---GFRDPFECNICGYHSQDRYEFSSHIV 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	11/24 (46%)
		COG5048	336..769	CDD:227381	92/424 (22%)
		zf-C2H2	348..370	CDD:278523	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	7/26 (27%)
		C2H2 Zn finger	630..650	CDD:275368	5/19 (26%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	689..707	CDD:275368
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Ikzf4	NP_035902.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..98		6/29 (21%)
		C2H2 Zn finger	161..181	CDD:275368	4/19 (21%)
		zf-H2C2_2	174..198	CDD:290200	9/23 (39%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		zf-H2C2_2	201..226	CDD:290200	11/24 (46%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..271	CDD:275368	6/20 (30%)
		Interaction with FOXP3. /evidence=ECO:0000269\|PubMed:19696312	281..586		66/346 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..490		13/87 (15%)
		CTBP-binding motif PEDLG	423..433		2/9 (22%)
		C2H2 Zn finger	533..553	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000