DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Ikzf3

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_035901.1	Gene:	Ikzf3 / 22780	MGIID:	1342542	Length:	507	Species:	Mus musculus

Alignment Length:	626	Identity:	127/626 - (20%)
Similarity:	207/626 - (33%)	Gaps:	188/626 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ELQHPRDEVVASDAAANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDS 166
            ||:...::.:.:::....|.:.....||.:.||:.|....|          |||..::.::..|.
Mouse     9 ELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSREAPANE----------DEDAGEDSMKVKDE 63

  Fly   167 FYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPH 231
             |||.             .:..|.|..                     .|.|:..::|
Mouse    64 -YSDR-------------DENIMKPEP---------------------MGDAEESEMP------- 86

  Fly   232 FHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQF 296
              :.:...|...:::|:...:...|                    .:.||        |...|..
Mouse    87 --YSYAREYSDYESIKLERHVPYDN--------------------SRPTG--------GKMNCDV 121

  Fly   297 CEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSD 361
            |..:......|..|.:||....||:|..|...|..|.:..||.||||.|:.:||..|..|..|.|
Mouse   122 CGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRD 186

  Fly   362 HLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASA 426
            .|..|::||.::||::|..|.|.|...::|..|.::.:   |.|.   ||:..:.:........|
Mouse   187 ALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCR---AFLQ---NPDLGDAASVEARHIKA 245

  Fly   427 SVSSNGSLQKRRYALALASDSSPSRMDFPKR--SRSNHVGGTTTTATPTPLLRCSYCP-----KV 484
            .:.|..:|...|    |||:.:..:...|::  ....|            ....:|.|     |.
Mouse   246 EMGSERALVLDR----LASNVAKRKSSMPQKFIGEKRH------------CFDANYNPGYMYEKE 294

  Fly   485 TEFSSLEQLN-------AHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRS 542
            .|......::       ::|.:...:|..|....|..|                 :..:...:..
Mouse   295 NEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSE-----------------MVPVISSVYP 342

  Fly   543 THMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRP---AEDDLPTDLSNNK 604
            ..:.|...||...:...:        .|:.|. .||.|.    ||...|   |:|...||.::..
Mouse   343 IALTRADMPNGAPQEMEK--------KRILLP-EKILPS----ERGLSPNNSAQDSTDTDSNHED 394

  Fly   605 RRPLTPN-----PQAQT--PL---APPS-----APP-----------------GVFFCNQCNAGL 637
            |:.|...     |||:.  ||   .|.|     .||                 .||.|:.|:...
Mouse   395 RQHLYQQSHVVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMDVFRCDHCHVLF 459

  Fly   638 PDFESFRNHLKSHIAEGMQ--LVCPHCGMSLPEQSEFERHV 676
            .|:..|..|:..|   |.:  ..|..||....::.||..|:
Mouse   460 LDYVMFTIHMGCH---GFRDPFECNMCGYRSHDRYEFSSHI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	11/24 (46%)
		COG5048	336..769	CDD:227381	88/392 (22%)
		zf-C2H2	348..370	CDD:278523	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368	5/19 (26%)
		C2H2 Zn finger	659..679	CDD:275368	6/18 (33%)
		C2H2 Zn finger	689..707	CDD:275368
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Ikzf3	NP_035901.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		20/120 (17%)
		COG5048	<105..>218	CDD:227381	40/140 (29%)
		C2H2 Zn finger	119..139	CDD:275368	4/19 (21%)
		zf-H2C2_2	132..156	CDD:290200	9/23 (39%)
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		zf-H2C2_2	159..182	CDD:290200	10/22 (45%)
		C2H2 Zn finger	175..195	CDD:275368	7/19 (37%)
		zf-H2C2_2	191..212	CDD:290200	9/20 (45%)
		C2H2 Zn finger	203..219	CDD:275368	5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..396		8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000