DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zfp64

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_033590.2	Gene:	Zfp64 / 22722	MGIID:	107342	Length:	676	Species:	Mus musculus

Alignment Length:	587	Identity:	122/587 - (20%)
Similarity:	197/587 - (33%)	Gaps:	178/587 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 EAEEGSEELQHPRDEVVASDAAANAN--GHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYD 157
            |.:..|..:|.|....|..:.|.:.:  |.||......||..|.:....:|....::......:.
Mouse     6 EGDTFSGSMQIPGGTTVLVELAPDIHICGLCKQHFSNLDAFVAHKQSGCQLTTTPVTAPSTVQFV 70

  Fly   158 DEELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDH----PTEGKINGGA 218
            .||.:.         :|.|:::   :||..|.|..    :.||....:..:    |||...|..|
Mouse    71 AEETEP---------ATQTTTT---TISSETQTIT----VSAPEFVFEHGYQTYLPTESTDNQTA 119

  Fly   219 DGEDLP------KPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFD 277
            ....||      ||...|                          .:.::|....|      .:|.
Mouse   120 TVISLPTKSRTKKPTAPP--------------------------AQKRLGCCYPG------CQFK 152

  Fly   278 KLTGEGIKS--------RGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRS 334
              |..|:|.        .||..::|:.|.|.|.|...||.|::.|....|:||:.|........|
Mouse   153 --TAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSS 215

  Fly   335 RDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHK 399
            .::|.::|::||.:||..|..|...|..|.:|:::|....||||.:|:..:..::.|..||:.|
Mouse   216 LNKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCWLCSAKFKISSDLKRHMRVH- 279

  Fly   400 KNAAILAAGGNPNALNY-SPRSTGSASAS----VSSNGSLQKRRYALALASDSSPSRMDFPKRSR 459
                   :|..|....: :.|.|...:..    :..:|:..|..:...|....|..|    |.||
Mouse   280 -------SGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKSTLR----KHSR 333

  Fly   460 ---SNHVGGTTTTATPTPLLRCSY-CPKVTEFSSLEQLNAHLQSVH--EQPQTQAVKTPVQEGEG 518
               |.|         |.....||| |      ||...|..| :.:|  |:|
Mouse   334 LHQSEH---------PEKCPECSYSC------SSKAALRVH-ERIHCTERP-------------- 368

  Fly   519 FQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLG 583
              ..|.||:......:.|.:||:..|.|.|.:.
Mouse   369 --FKCSYCSFDTKQPSNLSKHMKKFHADMLKNE-------------------------------- 399

  Fly   584 SPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLK 648
            :||::....:........:.|:                     .|.|:.|:|.....:|.|:|.:
Mouse   400 APEKKESGRQSSRQVARLDAKK---------------------TFHCDICDASFMREDSLRSHKR 443

  Fly   649 SH 650
            .|
Mouse   444 QH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	4/19 (21%)
		zf-H2C2_2	334..359	CDD:290200	9/24 (38%)
		COG5048	336..769	CDD:227381	67/326 (21%)
		zf-C2H2	348..370	CDD:278523	7/21 (33%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		C2H2 Zn finger	630..650	CDD:275368	6/19 (32%)
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	689..707	CDD:275368
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Zfp64	NP_033590.2	COG5048	<149..448	CDD:227381	87/396 (22%)
		zf-H2C2_2	159..184	CDD:290200	6/24 (25%)
		C2H2 Zn finger	175..195	CDD:275368	8/19 (42%)
		zf-H2C2_2	188..209	CDD:290200	8/20 (40%)
		C2H2 Zn finger	203..223	CDD:275368	4/19 (21%)
		zf-H2C2_2	215..237	CDD:290200	8/21 (38%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		zf-H2C2_2	271..295	CDD:290200	7/31 (23%)
		C2H2 Zn finger	287..306	CDD:275368	2/18 (11%)
		C2H2 Zn finger	343..363	CDD:275368	8/26 (31%)
		zf-H2C2_2	355..380	CDD:290200	8/41 (20%)
		C2H2 Zn finger	371..389	CDD:275368	5/17 (29%)
		zf-C2H2_6	422..448	CDD:290623	8/24 (33%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000