DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zfp521

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	1623	Identity:	381/1623 - (23%)
Similarity:	544/1623 - (33%)	Gaps:	668/1623 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRKQAKPRACLKLGEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGER 65
            ||||||||||:              |.:|..:|          |.:.||.|..|       ..:|
Mouse     1 MSRRKQAKPRS--------------LKDPNCKL----------EDKIEDGEAVD-------CKKR 34

  Fly    66 PQLVPNESQQQSWPTADEPAAPAAVAKEEEAEEGSEELQHPRDEVV-----ASDAAANANGHCKS 125
            |                           |:.||..|:..|..|..:     .||...:....|:.
Mouse    35 P---------------------------EDGEELEEDAVHSCDSCLQVFESLSDITEHKIHQCQL 72

  Fly   126 SGHEEDAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGTMT 190
            :    |.||.|                    ||                       ||.|....:
Mouse    73 T----DGVDVE--------------------DD-----------------------PSCSWPASS 90

  Fly   191 PNSHHLIGAPTAAGQEDHPTEGKINGGAD-GEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRK 254
            |:|.          .:..|:.|:   |.| ||:
Mouse    91 PSSK----------DQTSPSHGE---GCDFGEE-------------------------------- 110

  Fly   255 INKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDG-SYQCQFCEKTFPRLGYLKHHVQSHAEHL 318
                                       ||    |.| .|.||||:|:|.||.|||||.|||::.|
Mouse   111 ---------------------------EG----GPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL 144

  Fly   319 PFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNR 383
            ||||.|||:|||||||||||.||||.::.|.|..|:||||||||||||:|||...||::|::|.|
Mouse   145 PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRR 209

  Fly   384 GYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSS 448
            |:.::::|..|||.|::|                  ..||.|.|...:..::..:     .....
Mouse   210 GFLSSSSLHGHMQVHERN------------------KDGSQSGSRMEDWKMKDTQ-----KCSQC 251

  Fly   449 PSRMDFPKRSRSNHVGGTTTTATPT---PLLRCSYCPKV-------------------------- 484
            ....|||: ....|:.......:|.   ..|:|.||.::
Mouse   252 EEGFDFPE-DLQKHIAECHPECSPNEDRAALQCMYCHELFVEETSLMNHIEQVHGGEKKNSCSIC 315

  Fly   485 -TEFSSLEQLNAHLQSVHEQP-------------------------------------------- 504
             ..|.::|:|.:|:.| |:||
Mouse   316 SESFLTVEELYSHMDS-HQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPK 379

  Fly   505 ---------QTQAVKTPVQEGEGFQLSCEYCTMK-FGNIAGLFQHMRSTHMDR------------ 547
                     ||..:..|..:......||.||..: |.::|.|..|:::.|:|:
Mouse   380 SRGRKRAAQQTSDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLE 444

  Fly   548 -LSSPNSYYEHFNRLATAG----------------TFSPRLALDLPKIKPDLGSPERESRPAEDD 595
             |.|..:..||..::..|.                .|...:..||..::..:......:.||..|
Mouse   445 VLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKD 509

  Fly   596 -------------------------LPTDLS---------------------------------- 601
                                     :..|||
Mouse   510 SNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSV 574

  Fly   602 ---------NNKRRPLTPN-------PQAQTPLAP-----------------PSAPPGVFFCNQC 633
                     |:|..||..|       .:|.:||:|                 |:...|.:.||||
Mouse   575 LKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYICNQC 639

  Fly   634 NAGLPDFESFRNHLKSHIAEGM-QLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSF 697
            .|.....:||:.|||:|:...: :|.||.|....|.|....:||..||:||.:.:.| .||.|.|
Mouse   640 GAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYIC-ESCDKQF 703

  Fly   698 AKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFH 762
            ...:|||:|||..|.....:|:||.|:.:|::::|||||..||.|.|:.||::|...||::.:..
Mouse   704 TSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQ 768

  Fly   763 VHVKTRH---QLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFH 824
            :|||..|   |...|              :|:||.....:|:|:..|:..|::::.|..|.:.||
Mouse   769 LHVKHNHLENQGKVH--------------KCIFCGESFGTEVELQCHITTHSKKYNCRFCSKAFH 819

  Fly   825 VEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLF 889
            ...||::|::.:|...   |..:||.|                    ||
Mouse   820 AVILLEKHLREKHCVF---ETKTPNCG--------------------TN---------------- 845

  Fly   890 GGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKST 954
             |||.                         ||.....:.||             .|.....:.::
Mouse   846 -GASE-------------------------QVQKEEAELQT-------------LLTNSQESHNS 871

  Fly   955 SPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVS-- 1017
            .....|.|.:|:|                 .:.|.:|... ...|..|.:|:...||::.|.|
Mouse   872 HDGSEEDVDSSEP-----------------MYGCDICGAA-YTMETLLQNHQLRDHNIRPGESAI 918

  Fly  1018 -----------LRCAYCAGNFKSRAELEQHMKSCHNSTGKH-KCLICDEVFPSPAILAEHKLQHS 1070
                       .:|..|:..|.|...|.:||:: |....|| .|.||.|.|||...|.|||:.||
Mouse   919 VKKKAELIKGNYKCNVCSRTFFSENGLREHMQT-HLGPVKHYMCPICGERFPSLLTLTEHKVTHS 982

  Fly  1071 KVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLP-LACICCRQTLHSEFELSLHAKFHTKSSS 1134
            |...:|.|..|..||:....|..|...|.....||. ..|:.|.||:.|..||.:|..||.:.:.
Mouse   983 KSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTG 1047

  Fly  1135 SGGSLQEP----------VCALCLE-----------------------------------PLP-- 1152
            :|.|:|..          .||.||:                                   .||
Mouse  1048 NGSSVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSSSPGLSLPPG 1112

  Fly  1153 ------------DATEGPAKL------CDKCCRKHNLNGKRGKHSEP----------ATSLPAP- 1188
                        .|.||..|.      |..|..|.....:...|.:.          :|.|..|
Mouse  1113 ASRPGLGQNESLSAMEGKGKAGGLKTRCSSCNVKFESESELQNHIQTVHRELVPDANSTQLKTPQ 1177

  Fly  1189 --------PSAFVENR---------------------------------CNLCKMILPHAQKLQE 1212
                    ||...|.:                                 |.||........|||.
Mouse  1178 VSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQC 1242

  Fly  1213 HLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHGAHSRPYDCNLCPEKFFFRAELEHH 1274
            ||:||:|.|.... |.|.:|..||.....|..|: ..||...:.|||..||:||||:.||::|
Mouse  1243 HLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNH 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	322..342	CDD:275368	16/19 (84%)
		zf-H2C2_2	334..359	CDD:290200	15/24 (63%)
		COG5048	336..769	CDD:227381	153/638 (24%)
		zf-C2H2	348..370	CDD:278523	16/21 (76%)
		C2H2 Zn finger	350..370	CDD:275368	15/19 (79%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	630..650	CDD:275368	10/19 (53%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		10/62 (16%)
		COG5048	<83..236	CDD:227381	87/246 (35%)
		C2H2 Zn finger	120..140	CDD:275368	14/19 (74%)
		C2H2 Zn finger	148..168	CDD:275368	16/19 (84%)
		C2H2 Zn finger	176..196	CDD:275368	15/19 (79%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	248..265	CDD:275368	3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398		3/40 (8%)
		C2H2 Zn finger	407..428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	439..460	CDD:275368	4/20 (20%)
		C2H2 Zn finger	479..498	CDD:275368	3/18 (17%)
		C2H2 Zn finger	636..656	CDD:275368	10/19 (53%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	696..713	CDD:275368	8/17 (47%)
		C2H2 Zn finger	724..745	CDD:275368	10/20 (50%)
		C2H2 Zn finger	754..774	CDD:275368	7/19 (37%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883		2/19 (11%)
		C2H2 Zn finger	888..909	CDD:275368	5/21 (24%)
		C2H2 Zn finger	932..952	CDD:275368	7/20 (35%)
		C2H2 Zn finger	961..981	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136		6/30 (20%)
		C2H2 Zn finger	1227..1247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1258..1279	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1288..1307	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10746
eggNOG	1	0.900	-	-		E33208_3BE22
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3252
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222002at33208
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	1	1.000	-	-		oto95253
orthoMCL	1	0.900	-	-		OOG6_106906
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730