DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and spr-4

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_001020993.1	Gene:	spr-4 / 172596	WormBaseID:	WBGene00005009	Length:	1311	Species:	Caenorhabditis elegans

Alignment Length:	840	Identity:	157/840 - (18%)
Similarity:	254/840 - (30%)	Gaps:	289/840 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 HHHHHHHYHHQQALK--------IANKLRKINKEAKMGATAGGGATGAASKFDKL---------T 280
            |...|..:|....||        :...|.|:.:|.|.......|.......||.:         |
Worm   510 HTSTHKRFHRTYYLKECVGDKFFVKYNLSKVQEEVKEEPKEADGDESGDESFDSMCPASDVHPET 574

  Fly   281 GEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLH--- 342
            ...|:.: |..:.|..|....|.:...:.|...|.::..|||:|||...:.|.....|:|||
Worm   575 LAAIEMK-DVFFCCNMCPYKAPTMNRCQRHYDKHFKNDEFKCQYCSWSSRSKEVIVNHEKLHPTV 638

  Fly   343 ----TNE---------------------------------------------------------- 345
                |||
Worm   639 VVANTNEAPVVKNEIEAKVEVLSKTVSSPVECTEESSLSKSIQLWCQREKLRHPELDEQFTRKMI 703

  Fly   346 ---RNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAA 407
               :.::|..|.........::.|.|.|||::.::|..|....|...:|..|:::|    ||
Worm   704 DGVKGFQCTDCPYTSKYRGDMRSHKKRHDIEQLYRCVQCTYTTNRPVSLKDHLKQH----AI--- 761

  Fly   408 GGNPNALNYSPRSTGSASASVSSNGSLQKRR---------------YALAL-------------- 443
                  :|.|.....|....|:....:..||               ..|||
Worm   762 ------VNMSIADIKSRRVVVNQGVKIGMRRGVGKDKIYCCDKCPYVTLALGCLWRHHRNHRDTA 820

  Fly   444 ----ASDSSPSRMDFPKRSRSN--HVGGTTTTATPTPLLRCSYCPKVTE----FSSLEQLNAH-- 496
                .|:.|.|.:|..|.....  |:|.....|.|       :..:|.:    .|||..||:.
Worm   821 KINICSNCSYSSIDQRKMEEHTIIHLGLGLNEAVP-------FVKRVDQKGRPVSSLTDLNSEKM 878

  Fly   497 ----------LQSVH----------------------------EQPQTQAVKTPVQEGEGF---- 519
                      |..|.                            |:.:.|:.:.|..:.|.|
Worm   879 NERKSTKRKMLDKVEKMEVGEDEEDDEESVDKGTDDGDYKQRPEKKRKQSSEEPASDPELFGSSS 943

  Fly   520 ----QLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLA--TAGTFS----PRLALD 574
                ||| |..|....|.:     :.|.:.....:|::...:..:||  :.|..|    |..:::
Worm   944 QPTRQLS-ERATRNRINYS-----LLSKNGSGKPTPSTSSANLEKLAGSSGGASSESPEPDESVE 1002

  Fly   575 LPK------------IKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQA--------QTPLA 619
            :..            :|..|..|:...:.:|.|:............||.|.|        .||.|
Worm  1003 VSHWKIRTFLRSEYGVKESLKCPDCPYKSSEPDVLEKHRYYHMTKTTPRPYACSDCTFNTYTPTA 1067

  Fly   620 --------------------------PPSAPPGV--FFCNQCNAGLPDFES--FRNHLKSHIAEG 654
                                      ..|.||||  ::|..|:     |::  .||.:: |.|..
Worm  1068 LLQHLKLHSEGVYFDPMVKKHMKHRKGDSIPPGVKGYYCKNCS-----FKTSIHRNFIE-HSAYH 1126

  Fly   655 MQLVCPHCGMSL---PEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKS---EDLQQHLLSEHVL 713
            .|.:.....::|   |.:.|::|..:.|..:..:...|.....|..::|   |.|.:|..::
Worm  1127 RQQLINRINITLKRQPPRIEYQRPKLKHQFVAKNAKYCKKCTFKCVSQSNFIEHLDRHGWNQ--- 1188

  Fly   714 TLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFH-----VHVKTRHQLGG 773
             |.||..|.....::..:..|....|..:.:.|. |.|     ..|:|.     :.:........
Worm  1189 -LYKCYSCDYSDNTKSVVDFHQLNHHIVKDQTLH-SIC-----QSAKFRLENGVIQIPEFQTEKS 1246

  Fly   774 HPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHM 833
            .||.....|.....|:|..|...|....|:.||::.|  ....|:..||  :.:|   ||
Worm  1247 KPTPDEFVSKTRGLLKCPSCEYFCHVSSELAFHMSVH--HLTEPNARET--ISYL---HM 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	9/92 (10%)
		COG5048	336..769	CDD:227381	113/654 (17%)
		zf-C2H2	348..370	CDD:278523	4/21 (19%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		C2H2 Zn finger	630..650	CDD:275368	5/21 (24%)
		C2H2 Zn finger	659..679	CDD:275368	4/22 (18%)
		C2H2 Zn finger	689..707	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
spr-4	NP_001020993.1	C2H2 Zn finger	114..134	CDD:275368
spr-4	NP_001020993.1	C2H2 Zn finger	143..163	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I3336
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050