Protein Alignment L and ZNF579

DIOPT Version :10

• Sequence 1: NP_001188929.1
• Gene: L / 36609
• FlyBaseID: FBgn0288433
• Length: 1366
• Species: Drosophila melanogaster
• Sequence 2: XP_016881898.1
• Gene: ZNF579 / 163033
• HGNCID: 26646
• Length: 640
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 152/670 - (22%)
• Similarity: 209/670 - (31%)
• Gaps: 206/670 - (30%)

  Fly   746 LRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAH 810
            |.|..|..|||    |..:: :||:|         |.:...|..|..|.........:..||..|
Human    44 LPCPTCGRLFR----FPYYL-SRHRL---------SHSGLRPHACPLCPKAFRRPAHLSRHLRGH 94

  Fly   811 ARQ--FRCPSCPETFHVEFLLDRHMQSQHGGVK--------DKEANSPNMGSLYVNALLPPLAAA 865
            ..|  .||.:||.||.....|.||:..:|.|.:        .||...|:.|.
Human    95 GPQPPLRCAACPRTFPEPAQLRRHLAQEHAGGEVELAIERVAKETAEPSWGP------------- 146

  Fly   866 AAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQT 930
                                                 ...|..||            |.|....|
Human   147 -------------------------------------QDEGSEPP------------TTAAAGAT 162

  Fly   931 SPHPALMYGLSQRYLMEMYAA-KSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQ 994
            ..              |..|| ..|.|:|..    |...||.:.|.|....:..|  ..|..|
Human   163 EE--------------EAVAAWPETWPAGEP----STLAAPTSAAEPRESESEEA--EAGAAE-- 205

  Fly   995 DLRSEAELHSHRKLAHN--LKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTG------------ 1045
             ||:|..|.:.|:....  |:...:|.|..|...|.::.||:.|  .|....|
Human   206 -LRAELALAAGRQEEKQVLLQADWTLLCLRCREAFATKGELKAH--PCLRPEGEQEGEGGPPPRP 267

  Fly  1046 -KHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLPLAC 1109
             :|:|.||.:.|..|..|:.|:|.|| ..:...|..||......:..|.|...||      ||:.
Human   268 KRHQCSICLKAFARPWSLSRHRLVHS-TDRPFVCPDCGLAFRLASYLRQHRRVHG------PLSL 325

  Fly  1110 ICCRQTLHSEFELSLHAKFHTKSSSSGGSLQEP------VCALCLEPLPDATEGPAKLCDKCCRK 1168
            :.         .|....|...|:|.:..|.:.|      .|.       .|:||.
Human   326 LA---------PLPAAGKKDDKASGARNSAKGPEGGEGAECG-------GASEGG---------- 364

  Fly  1169 HNLNGKRGKHSEPATSLPAPPSAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICS 1233
               .|:.|..:.||    .||:......|..|.........|::|.|.|:.|    |.|.|..|.
Human   365 ---EGQNGGDAAPA----RPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGA----RPFQCVRCQ 418

  Fly  1234 AVFTAPGGLLNHMGEHGAHSRPYDCNLCPEKFFFRAELEHHQRGH--ELRPQARPPAAKVEVPSI 1296
            ..|.....|..|...|.....|:.|..||.:|.....|..|||.|  ||...|...|.:.:.|
Human   419 REFKRLADLARHAQVHAGGPAPHPCPRCPRRFSRAYSLLRHQRCHRAELERAAALQALQAQAP-- 481

  Fly  1297 RNTSPGQSPVRSPTIVKQELYETDTVESAGVEDE-------PENHP-----------DEEEYIEV 1343
              |||...|   |.:..::..|...:..|.:::|       |::.|           |.:::...
Human   482 --TSPPPPP---PPLKAEQEEEGLPLPLANIKEEPPSPGTPPQSPPAPPVFLSASCFDSQDHSAF 541

  Fly  1344 EQMPHETRPSGI--GSQLER 1361
            |....|....|.  |.||.|
Human   542 EMEEEEAGRLGKKGGGQLAR 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368
		COG5048	336..769	CDD:227381	7/22 (32%)
		C2H2 Zn finger	350..370	CDD:275368
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	689..707	CDD:275368
		C2H2 Zn finger	1020..1041	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1049..1069	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1197..1217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1229..1246	CDD:275368	4/16 (25%)
		C2H2 Zn finger	1258..1278	CDD:275368	8/19 (42%)
ZNF579	XP_016881898.1	COG5048	45..>105	CDD:227381	19/73 (26%)
		C2H2 Zn finger	46..66	CDD:275368	9/33 (27%)
		zf-C2H2	72..94	CDD:395048	4/21 (19%)
		C2H2 Zn finger	74..94	CDD:275368	4/19 (21%)
		C2H2 Zn finger	102..119	CDD:275368	7/16 (44%)
		C2H2 Zn finger	232..254	CDD:275368	7/23 (30%)
		C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		zf-C2H2	298..320	CDD:395048	5/21 (24%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)