DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ZXDB

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_009088.1	Gene:	ZXDB / 158586	HGNCID:	13199	Length:	803	Species:	Homo sapiens

Alignment Length:	1047	Identity:	207/1047 - (19%)
Similarity:	311/1047 - (29%)	Gaps:	391/1047 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGERPQLVPNESQQQSWPT 80
            |.:.:|.:|....|...||:...|.....|              ||||:...||..:.......|
Human    56 GRRREEASTASRGPGPSLLAPRTDQPSGGG--------------GGGGDDFFLVLLDPVGGDVET 106

  Fly    81 ADEPAAPAAVAKEEEAEEGSEELQHPRDEVVASDAAANANG-HCKSSGHEEDAVDAEEPEDLELD 144
            |....|...|.: |||||| ..||  ..|..|:.|...|.| .|.|:        ...|..:...
Human   107 AGSGQAAGPVLR-EEAEEG-PGLQ--GGESGANPAGPTALGPRCLSA--------VPTPAPISAP 159

  Fly   145 DELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSY------SPSISDGTM-TPNSHHLIGAPTA 202
            ....:.:|.....:::|  |..|.:.:.:..|...:      :|:...|.: .|.:    |.|.|
Human   160 GPAAAFAGTVTIHNQDL--LLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQA----GFPHA 218

  Fly   203 AGQEDHPTEGKINGGADGEDLP---------KPKRLPHFHHHHHHHYHHQQALKIANKLRKINKE 258
            |    ||        .|..:||         :|...|                        ..:|
Human   219 A----HP--------GDCPELPPDLLLAEPAEPAPAP------------------------APEE 247

  Fly   259 AKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQC--QFCEKTFPRLGYLKHHVQSHAE---HL 318
            ...|..|..|..|...     :|.|:.     .|.|  ..|.:||.:...||.|:.:|:.   ..
Human   248 EAEGPAAALGPRGPLG-----SGPGVV-----LYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQR 302

  Fly   319 PFKCEY--CSKLFKHKRSRDRHKKLHTNERNYKCP--HCEAAFSRSDHLKIHMKTHDIQKPFQCS 379
            ||||..  |...|.......||.:.|...|.:.||  .|..:|:...:||.|||.|:.:..|:|.
Human   303 PFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCE 367

  Fly   380 MCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALA 444
            :|...:.|.|.|::|.:.|                 :.|
Human   368 VCEESFPTQAKLSAHQRSH-----------------FEP-------------------------- 389

  Fly   445 SDSSPSRMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAV 509
                                                                     |:|
Human   390 ---------------------------------------------------------ERP----- 392

  Fly   510 KTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALD 574
                     :|.:...|...|..::.||.|.|:              ||.
Human   393 ---------YQCAFSGCKKTFITVSALFSHNRA--------------HFR--------------- 419

  Fly   575 LPKIKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCN--QCNAGL 637
                       |:|                                      :|.|:  .|:...
Human   420 -----------EQE--------------------------------------LFSCSFPGCSKQY 435

  Fly   638 PDFESFRNHLKSHIAEGMQLVCPH--CGMSLPEQSEFERHVVGHFLITGSEFNCS-SSCGKSFAK 699
            ......:.||:||..| ...:|..  ||.:....|:..||...|  .....|.|. ..|||||.:
Human   436 DKACRLKIHLRSHTGE-RPFLCDFDGCGWNFTSMSKLLRHKRKH--DDDRRFMCPVEGCGKSFTR 497

  Fly   700 SEDLQQHLLSEHVLTLLKCSL--CSELCESRMAMQLHLACAHSQ--ETKLLRC--SACLELFRSD 758
            :|.|:.|.::........|.:  |.....:|.::.:| :..|.|  :|...||  |:|.:||.|.
Human   498 AEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIH-SKKHLQDVDTWKSRCPISSCNKLFTSK 561

  Fly   759 AEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETF 823
            .....|:..||::|........::....|          ||||       ...||
Human   562 HSMKTHMVKRHKVGQDLLAQLEAANSLTP----------SSEL-------TSQRQ---------- 599

  Fly   824 HVEFLLDRHMQSQHGGVKDKEANS------PNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYN 882
              ..|.|..:.|....|.|..:.:      .|.|.|.::  :..:::..|.....|||:|:
Human   600 --NDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTID--VASVSSTLAGHLPANNNNSV---- 656

  Fly   883 VAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQ-VDTNALKAQTSPHPALMYGLSQRYL- 945
                              |.|..   |||......|.| :||:......:.      |..|..|
Human   657 ------------------GQAVD---PPSLMATSDPPQSLDTSLFFGTAAT------GFQQSSLN 694

  Fly   946 MEMYAAKSTSPSG---NEGVGNSQPPAPQATAPPPPPNAST--ATFSCGMCERQDLRSEAELHSH 1005
            |:..::.|..|.|   :..:.||. |.|||..|.......|  .|.|..:||    .|.:||.:.
Human   695 MDEVSSVSVGPLGSLDSLAMKNSS-PEPQALTPSSKLTVDTDALTPSSTLCE----NSVSELLTP 754

  Fly  1006 RKLAHNL 1012
            .|...|:
Human   755 TKAEWNV 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/21 (33%)
		C2H2 Zn finger	322..342	CDD:275368	5/21 (24%)
		zf-H2C2_2	334..359	CDD:290200	8/26 (31%)
		COG5048	336..769	CDD:227381	76/445 (17%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368	4/21 (19%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
ZXDB	NP_009088.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..140		10/22 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..260		13/77 (17%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	271..577		94/501 (19%)
		C2H2 Zn finger	273..295	CDD:275368	7/21 (33%)
		zf-C2H2_aberr	304..449	CDD:293622	47/336 (14%)
		zf-C2H2	304..328	CDD:278523	7/23 (30%)
		C2H2 Zn finger	306..328	CDD:275368	5/21 (24%)
		C2H2 Zn finger	336..358	CDD:275368	9/21 (43%)
		zf-H2C2_2	350..373	CDD:290200	9/22 (41%)
		zf-C2H2	364..386	CDD:278523	7/21 (33%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..417	CDD:275368	6/35 (17%)
		C2H2 Zn finger	429..448	CDD:275368	3/18 (17%)
		COG5048	<441..572	CDD:227381	37/134 (28%)
		C2H2 Zn finger	456..478	CDD:275368	6/21 (29%)
		zf-H2C2_2	471..497	CDD:290200	10/27 (37%)
		C2H2 Zn finger	486..508	CDD:275368	9/21 (43%)
		C2H2 Zn finger	516..538	CDD:275370	4/22 (18%)
		Required for transcriptional activation. /evidence=ECO:0000250	576..703		33/188 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46179
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100