DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and znf521

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_004915266.1	Gene:	znf521 / 101731404	XenbaseID:	XB-GENE-6459826	Length:	1312	Species:	Xenopus tropicalis

Alignment Length:	1629	Identity:	377/1629 - (23%)
Similarity:	536/1629 - (32%)	Gaps:	679/1629 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRKQAKPRACLKLGEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGER 65
            ||||||||||:              |.:|..:|   ::.:||.|..|
Frog     1 MSRRKQAKPRS--------------LKDPNCKL---EDKSEDGESTD------------------ 30

  Fly    66 PQLVPNESQQQSWPTADEPAAPAAVAKEEEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEE 130
                                   ...::||.:|..||..|..|.             |
Frog    31 -----------------------CKKRQEEGDELEEEAVHSCDS-------------C------- 52

  Fly   131 DAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHH 195
                                          ||..:                 |:||.|     .|
Frog    53 ------------------------------LQVFE-----------------SLSDIT-----EH 65

  Fly   196 LIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAK 260
            .|            ::.::..|||.||.|
Frog    66 KI------------SQCQLTDGADVEDDP------------------------------------ 82

  Fly   261 MGATAGGGATGAASK----------FDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHA 315
               |....|:..:||          ||....|||...   .|.||||:|:|.||.|||||.|||:
Frog    83 ---TCSWPASSPSSKDQASPIHGEGFDFGEEEGIPGL---PYPCQFCDKSFSRLSYLKHHEQSHS 141

  Fly   316 EHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSM 380
            :.|||||.|||:|||||||||||.||||.::.|.|..|:||||||||||||:|||...||::|::
Frog   142 DKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAI 206

  Fly   381 CNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALAS 445
            |.||:.::::|..|||.|::|.....:|...:  .:..:.|...|
Frog   207 CRRGFLSSSSLHGHMQVHERNKDCSQSGSRMD--EWKMKDTQKCS-------------------- 249

  Fly   446 DSSPSRMDFPKRSRSNHVGGTTTTATPT---PLLRCSYCPKV----------------------- 484
             ......|||: ....|:.......:|.   ..|:|.||.::
Frog   250 -QCEEGFDFPE-DLQKHIAECHPECSPNDDRAALQCMYCHELFVEETSLLNHMEQIHNSEKKNSC 312

  Fly   485 ----TEFSSLEQLNAHLQSVHEQP----------------------------------------- 504
                ..|.|:|:|.:|:.| |:.|
Frog   313 NICSENFHSIEELYSHMDS-HQHPESCNPSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEVAPP 376

  Fly   505 ------------QTQAVKTPVQEGEGFQLSCEYCTMK-FGNIAGLFQHMRSTHMDR--------- 547
                        ||..|..|..:......||.||:.: |.::|.|..|:::.|:|:
Frog   377 LTKGRGRKRAVQQTGDVNAPTSKQAKVSYSCIYCSKQLFSSLAVLQIHLKTMHLDKPEQAHICQY 441

  Fly   548 ----LSSPNSYYEHFNRLATAGTFSPRLAL------------------DLPKIKPDLGSPERESR 590
                |.|..:..||..::..  |..|.|.:                  ||..::..:.|....:.
Frog   442 CLEVLPSLYNLNEHLKQVHE--TQDPALIVSTMPAMVYQCNFCSEIFNDLNVLQDHIRSSHGFAN 504

  Fly   591 PAEDD-------------------------LPTDLS----------------------------- 601
            |...|                         :..|||
Frog   505 PVAKDSNAFFCPHCYMGFLTDTSLEEHIRQVHCDLSNSRFGSPVLGTPKEPVVEVYSCSYCTNSP 569

  Fly   602 --------------NNKRRPLTPN-------PQAQTPLAP-----------------PSAPPGVF 628
                          |:|..||..|       .:|.:||:|                 ||.|.|.:
Frog   570 IFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRAMSPLSPVTLEQSSLKMMQSFGGTPSRPAGEY 634

  Fly   629 FCNQCNAGLPDFESFRNHLKSHIAEGM-QLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSS 692
            .||||.|.....:.|:.|||:|:...: :|.||.|....|.|....:||..||:||.:.:.| .|
Frog   635 ICNQCGAKYTSLDGFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYIC-ES 698

  Fly   693 CGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRS 757
            |.|.|...:|||:|||..|.....:|:||.|:.:|::::|||||..||.|.|:.||::|...||:
Frog   699 CDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRT 763

  Fly   758 DAEFHVHVKTRH---QLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSC 819
            :.:..:|||..|   |...|              :|:||.....:|:|:..|:..|::::.|..|
Frog   764 ETDLQLHVKHNHLENQGKIH--------------KCIFCGESFGTEVELQCHITTHSKKYNCKFC 814

  Fly   820 PETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVA 884
            .:.||...||::|::.:|...:.|..|                       ..||
Frog   815 SKAFHAIILLEKHLREKHCVFESKTQN-----------------------CGTN----------- 845

  Fly   885 FKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMY 949
                  |||.                         |:....::.||             .|....
Frog   846 ------GASE-------------------------QIQKEEVELQT-------------LLTNNQ 866

  Fly   950 AAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHNLKT 1014
            .:.::.....|.:..|:|                 .:.|.:|... ...|..|.:|:...||::.
Frog   867 ESHNSHDGSEEDIDTSEP-----------------MYGCDICGAA-YTMETLLQNHQLRDHNIRP 913

  Fly  1015 GVS-------------LRCAYCAGNFKSRAELEQHMKSCHNSTGKH-KCLICDEVFPSPAILAEH 1065
            |.|             .:|..|:..|.|...|.:||:: |....|| .|.||.|.|||...|.||
Frog   914 GESAIIKKKAELIKGNYKCNVCSRTFFSEGGLREHMQT-HLGPVKHYMCPICGERFPSLLTLTEH 977

  Fly  1066 KLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLP-LACICCRQTLHSEFELSLHAKFH 1129
            |:.|||...:|.|..|..||.....|..|...|.....||. ..|:.|.||:.|..||.:|..||
Frog   978 KVTHSKSLDTGNCRICKLPLHSEEDFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFH 1042

  Fly  1130 TKSSSSGGSLQEP----------VCALCLEPLP--------DATEGPAKLCDKCCR-----KHNL 1171
            .:.:.:...:|..          .||.||:...        |....|..||..|..     ..|.
Frog  1043 MQKTGTATPIQSAGRVQNLQKLFKCASCLKEFRSKQDLVKLDINGLPYGLCASCVNLSKSASPNA 1107

  Fly  1172 N--------------------GKRGK----------------------------HSE-----PAT 1183
            |                    ||..|                            |.|     ..|
Frog  1108 NVTLSSNRQVISQTDSLTCVEGKNNKTSVLKTRCSSCNVKFESETELQNHIQTIHRELVSENSTT 1172

  Fly  1184 SLPAP---------PSAFVENR---------------------------------CNLCKMILPH 1206
            .|..|         ||...|.:                                 |.||......
Frog  1173 QLKTPQVSPMARISPSQSEEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDS 1237

  Fly  1207 AQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHGAHSRPYDCNLCPEKFFFRAE 1270
            ..|||.||:||:|.|.... |.|.:|..||.....|..|: ..||...:.|||..||:||||:.|
Frog  1238 PAKLQCHLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCAQCPQKFFFQTE 1301

  Fly  1271 LEHH 1274
            |::|
Frog  1302 LQNH 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	322..342	CDD:275368	16/19 (84%)
		zf-H2C2_2	334..359	CDD:290200	15/24 (63%)
		COG5048	336..769	CDD:227381	155/640 (24%)
		zf-C2H2	348..370	CDD:278523	16/21 (76%)
		C2H2 Zn finger	350..370	CDD:275368	15/19 (79%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	630..650	CDD:275368	9/19 (47%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
znf521	XP_004915266.1	C2H2 Zn finger	120..140	CDD:275368	14/19 (74%)
		C2H2 Zn finger	148..168	CDD:275368	16/19 (84%)
		C2H2 Zn finger	176..196	CDD:275368	15/19 (79%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	248..265	CDD:275368	4/38 (11%)
		C2H2 Zn finger	407..428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	439..460	CDD:275368	4/20 (20%)
		C2H2 Zn finger	479..497	CDD:275368	2/17 (12%)
		C2H2 Zn finger	636..656	CDD:275368	9/19 (47%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	696..713	CDD:275368	8/17 (47%)
		C2H2 Zn finger	724..745	CDD:275368	10/20 (50%)
		C2H2 Zn finger	754..774	CDD:275368	7/19 (37%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	7/17 (41%)
		C2H2 Zn finger	888..909	CDD:275368	5/21 (24%)
		C2H2 Zn finger	932..952	CDD:275368	7/20 (35%)
		C2H2 Zn finger	961..981	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1228..1248	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1259..1280	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1289..1308	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10599
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I2980
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222002at33208
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970