DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oaz and ikzf2

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_017213106.1	Gene:	ikzf2 / 100150224	ZFINID:	ZDB-GENE-100922-169	Length:	499	Species:	Danio rerio

Alignment Length:	702	Identity:	146/702 - (20%)
Similarity:	217/702 - (30%)	Gaps:	267/702 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 TSSSYSPSISD--------------GTMTPNSH--HLIGAPTA------AGQEDHPTEGKING-- 216
            ||:.|..|..|              .|.|||..  |...:|.|      .|.|:. ||.:..|
Zfish     3 TSNGYIESNGDCSPRKENSRMLVDLSTSTPNGQRSHSPQSPAARTIKQEEGTEEE-TERRAGGPD 66

  Fly   217 -----GADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGA-----TG 271
                 |.:|..|..|                  .:...|.|:          .||.||     ||
Zfish    67 EAGHSGEEGSGLEDP------------------MIDSPNNLQ----------DAGPGAEVQNETG 103

  Fly   272 AASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRD 336
            ......|..|:                                   .||:|..|...|..|.:..
Zfish   104 IRLPNGKYNGD-----------------------------------RPFQCNQCGVSFTQKGNLL 133

  Fly   337 RHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQK-HKK 400
            ||.||||.|:.:|||.|..|..|.|.|..|::||.:.||.:|:.|.|.|....:|..|.:: |
Zfish   134 RHIKLHTGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRTSLEEHKERCH-- 196

  Fly   401 NAAILAAGGNPNALNYSPRSTGSASASVSS--NGSLQKRRYALALASDSSPSRMDFPKRSRSNHV 463
                          ||. :|.|..|||...  .|.:.|.:..|..|..::..|....:|.:.| |
Zfish   197 --------------NYL-QSVGMDSASNPGPYPGEVPKEQRPLEPAGMAAFDRPPVIERLQGN-V 245

  Fly   464 GGTTTTATP-----TPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSC 523
            |...:| ||     ..::|.||          .:||..:...:|           :|.|..|
Zfish   246 GKRKST-TPQKFVGEKMVRYSY----------PELNYEMGLKYE-----------KEAELMQ--- 285

  Fly   524 EYCTMKFGNIAGLFQHMRSTHMDRLSS----PNSYYEHFNRLATAGTFSPRLALD--LPKIKPDL 582
                      |.:..|..|..:..|.|    |..::             |.|::.  :|.:.| |
Zfish   286 ----------AQMMDHALSNAISYLGSDSLRPMMHH-------------PSLSMAEVVPMVNP-L 326

  Fly   583 GSP-----ERESRPAEDDLPTDLSNNKRRPL-TPNPQ------AQTPLAPPSAPPGVFFCNQCNA 635
            ..|     .|..||:..:.|         |: .|||:      ...||..|..|......:.||:
Zfish   327 FHPVYPIGPRMDRPSSREAP---------PMPQPNPEFPQPTNGAIPLVRPKNPQSAQDGSPCNS 382

  Fly   636 GLPDFESFRNHLKSHIAEGMQLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKS 700
            |....:|.|:..:..::                             .||.....|    ..|.::
Zfish   383 GQDSADSARSSPRDKLS-----------------------------ATGPRLRSS----PGFGRA 414

  Fly   701 EDLQQHLLSEHVLTLLKCSLCSELCESRMAMQ--LHLACAHSQETKLLRCSACLELFRSDAEFHV 763
            |:.:                  .:..||:|.:  :.:.....||.::.:|..|..||.....:.:
Zfish   415 EEGR------------------SMEASRVAARDGVRVFAREGQELRVFQCEHCRVLFLDHVMYTI 461

  Fly   764 HVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFR 815
            |      :|.|        ...:||:|..|........|...|:......||
Zfish   462 H------MGCH--------GYRDPLECNICGHCSKDRYEFSSHIVRGEHTFR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	0/19 (0%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	12/24 (50%)
		COG5048	336..769	CDD:227381	99/460 (22%)
		zf-C2H2	348..370	CDD:278523	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	630..650	CDD:275368	5/19 (26%)
		C2H2 Zn finger	659..679	CDD:275368	0/19 (0%)
		C2H2 Zn finger	689..707	CDD:275368	3/17 (18%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
ikzf2	XP_017213106.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000