DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phyl and MAG

DIOPT Version :9

Sequence 1:	NP_725394.1	Gene:	phyl / 36606	FlyBaseID:	FBgn0013725	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_002352.1	Gene:	MAG / 4099	HGNCID:	6783	Length:	626	Species:	Homo sapiens

Alignment Length:	297	Identity:	62/297 - (20%)
Similarity:	98/297 - (32%)	Gaps:	92/297 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LNEDKFLCFSCNNW----LINWHSLQAVNSNEAESQSQSPSHMGNSVLQQE-----RTKLRPVAM 119
            |.||:      ..|    |:::...:..|.:....|:..|    |:.||.|     ..|..||.:
Human   189 LREDE------GTWVQVSLLHFVPTREANGHRLGCQASFP----NTTLQFEGYASMDVKYPPVIV 243

  Fly   120 -VRPTVRVQPQSQPQLQPQVPINPTPAPIVYSKRRASRRSASVSRMSRVLRQCCVESLRRSPKKR 183
             :..:|.....|...|......||.|.             .:..|...|||:...|||....::.
Human   244 EMNSSVEAIEGSHVSLLCGADSNPPPL-------------LTWMRDGTVLREAVAESLLLELEEV 295

  Fly   184 N--QQSVFVCLRPQGQKRSNAICKVECVAPRRKPVERLVKDVAATATPTPVLNTQSTPTYQRFPQ 246
            .  :..|:.||......:.|.                           |..|:....|.     :
Human   296 TPAEDGVYACLAENAYGQDNR---------------------------TVGLSVMYAPW-----K 328

  Fly   247 PSVDGKVVAMFRRLGTTLSREEPAAYSAESNPACSKLPQIMSPLKEAPRWTRDLDDDEILLEFDT 311
            |:|:|.:||:   .|.|:|    ...|.:|||     ..|::..||....:..:.:.|:.||
Human   329 PTVNGTMVAV---EGETVS----ILCSTQSNP-----DPILTIFKEKQILSTVIYESELQLE--- 378

  Fly   312 AISEVLPTARYQVTHE-----ENKENQQAQEMELELE 343
                 ||....:...|     ||:..|:|....|.:|
Human   379 -----LPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phyl	NP_725394.1	zf-AD	28..91	CDD:285071	6/30 (20%)
MAG	NP_002352.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		34/185 (18%)
		Ig_Siglec_N	22..139	CDD:143189
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128
		Ig	141..223	CDD:325142	8/43 (19%)
		Ig_3	239..309	CDD:316449	18/82 (22%)
		IG_like	333..409	CDD:214653	24/95 (25%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12205
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950