DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and SSB

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001281074.1	Gene:	SSB / 6741	HGNCID:	11316	Length:	408	Species:	Homo sapiens

Alignment Length:	298	Identity:	59/298 - (19%)
Similarity:	131/298 - (43%)	Gaps:	34/298 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 LAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRVRQLTREWKVVGDAV-RRK 344
            |.|:|...:|:||.:.::.:|.||.:.::.: ||:|.|:::..|.|:.:||.::.|:.:|: :.|
Human    13 LEAKICHQIEYYFGDFNLPRDKFLKEQIKLD-EGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSK 76

  Fly   345 SRKIELNDVGTKVRR--IEPLP----SFDETMPSRTIVACDLPLDKLTIEKVSDLFSPCGEI--- 400
            :..:|:::..||:||  .:|||    .:...:.:|::.....|.| .|::.:.:.....|::
Human    77 AELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTD-ATLDDIKEWLEDKGQVLNI 140

  Fly   401 ----ALIRILKPGMAIPVDVRQFMNKY---PELQQKECALV------EYLESSSARDARHLNGPF 452
                .|.:..|..:.:..|..:...|:   |..:.||..|:      .:.:.:..|....:....
Human   141 QMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKL 205

  Fly   453 QVYEMVAPKKKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRGGSFSGHETVPDLRF--KLKR 515
            :..:....|:|..:.|.:..:...:..:::.....:|..........||.|..:..:.|  ..|.
Human   206 RAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKE 270

  Fly   516 NNSDFQPSYYQQTGPSYHANPYQHYQPRGSIGNQNQEV 553
            ....|:....:..|.:..||       .|::..:|:||
Human   271 GIILFKEKAKEALGKAKDAN-------NGNLQLRNKEV 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	22/77 (29%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	17/114 (15%)
SSB	NP_001281074.1	LARP_3	10..91	CDD:153397	23/78 (29%)
		RRM1_La	112..183	CDD:240737	12/71 (17%)
		RRM_3	231..334	CDD:370115	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..408
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810