DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Achl and larp1b

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_005158614.1	Gene:	larp1b / 568156	ZFINID:	ZDB-GENE-030131-4154	Length:	1111	Species:	Danio rerio

Alignment Length:	906	Identity:	160/906 - (17%)
Similarity:	278/906 - (30%)	Gaps:	350/906 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 STSEDTSPSAPPMSPTDHQLVDVGMGSSIG-----------DSDESSEEGDELKPLAVD------ 164
            :||.:.....||...|.|....|....:.|           :.:.||.|.:..|...|:
Zfish    35 TTSHEEGQQDPPQGDTKHPKQGVMESKADGLSTDSTNDKENEQNASSHEAETAKKKVVEAPPPKV 99

  Fly   165 -----------NHIIAEVDLTERQTTP--PAVLSEANLEKFRKHQMDNIYLHPNFTLDASPPPAV 216
                       |:    .:.:.:||.|  ||.:..|:..:.||....:     :|:...:.|...
Zfish   100 NPWTKRNSCPPNN----TNNSSQQTEPQSPAKVVRASKPRSRKTSKSS-----DFSDITNWPTPG 155

  Fly   217 APAN----------------SPVLEAKRTH------------------------RSFLTMKKEKE 241
            ..||                |...|.|:.|                        .|...:..|:|
Zfish   156 ELANKEQQQNVINTQGRKGTSGRRERKKDHGGEKRDKESGSDGSDSKENREAQSNSITGLSNEQE 220

  Fly   242 VEPPQEKEQEVP-----VHQEQD-------TEPQGPN---------------------------- 266
            .|..:|.....|     ..:|:|       ...:|.|
Zfish   221 AEDGEETHSSAPRRRGGWRRERDFFDDTASVRSEGSNVRGGLRGRGKGRGRGRGRGRGRGDYSLS 285

  Fly   267 -EIDTLDPSLIPS----------------------EELAAE-ITDAVEFYFSNESILKDAFLLKH 307
             ....||.:.:|:                      |.|..| |...:|:|||..::.:|.||.:
Zfish   286 YRDSYLDGNSVPAEFGTNMVYYYNDGNRVQMYTIEENLLKEYIKRQIEYYFSLPNLERDFFLRR- 349

  Fly   308 VRRNKEGFVSLKLVSSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIE-----PLPSF- 366
             |.:.:||:.:.|::||.||:.||.:..::.:|: :.|..:||  |..::||.|     |:|:.
Zfish   350 -RMDSKGFLPISLIASFHRVQALTTDINLIKEAL-KNSEVVEL--VDEQIRRKEEPEQWPIPALA 410

  Fly   367 --------------DETMPSRTIVACDL-----------------------------------PL 382
                          .|.:|.:|..:...                                   |.
Zfish   411 LDSPRTDFSQLINCPEFVPGQTFTSLSTVSSSPVNQHMDEPSLVNGQTSDETDTAKPQSKESSPS 475

  Fly   383 DKLTI---------EKVSDLFSPCGEIALIRILK-----------------------------PG 409
            |..:.         |:.|.|..|..: ..|::.|                             |.
Zfish   476 DSKSSSGEDGSNLKERSSSLSDPDAQ-PWIQVEKRHRNTSGKNKTSVTPLPPSPPSSPPPPPPPS 539

  Fly   410 MAIPVDVRQFMNKYPELQQKECALVEYL-ESSSARDARHLNGPF--QVYEMVAPKKKT------- 464
            ...|:...:|   :|..::.|  ||:.. :.....|...|:..|  ::.::.||:|.|
Zfish   540 PPPPIPRLEF---FPSAERTE--LVQSTPKPQPEADQEELDFLFDEEMEQLAAPRKNTFTDWSDD 599

  Fly   465 ----------GKKAAVIQIAAPVARMVENYRYYNDANYERSRGGSFSG-HETVPDLRFKLKR--N 516
                      ..|..::....|..|              :..||..:| |.:...:...|.:  |
Zfish   600 DSDDELDDRDVNKILIVTQTPPHLR--------------KHPGGDRTGNHVSRAKITADLAKAIN 650

  Fly   517 NSDFQPSYYQQ------TGPSYHAN----------------PYQHYQPRGSIGNQNQEVGPNGFF 559
            :..|   ||:|      .||...||                .::...|:..| :.||||.|
Zfish   651 DGLF---YYEQDLWTKEEGPPECANAKEMENFKKLNMISQDEFETLTPKLPI-DPNQEVPP---- 707

  Fly   560 GYGPRRYSNTSTISANTAAALGDVSPISSAVNSGGNPMVSGISSLQRRLSNCSEQNYTPEVNPSM 624
              .|...::.|:::.:..|   ||...||...:...|...|          ..:...||...|.:
Zfish   708 --PPPCQTDDSSMAHSLPA---DVPESSSVPRTPRTPRTPG----------RQDPTKTPRFYPVI 757

  Fly   625 SRRASNCSETGGVPQRRDSNCSESCPCSRRVSDFAQTTDTSYRKTSVCSNGSCPGNNQNQERRFS 689
            ...:.|..  |..|::|.:..|.:.|....|.....:.:...|.:|:.|:.:.|          |
Zfish   758 KEDSGNLD--GKTPRKRKTRHSSNPPLECHVGWVMDSREHRPRTSSISSSNASP----------S 810

  Fly   690 NGSMQFERTFSNASESSGFYRRPSNDFNIEREPIQTDQLVGGGGGGYQVWPRRYSNNFQQL 750
            .|:.....::....:|...:..||::  :.||...|.|:       |..:.||..|..::|
Zfish   811 EGAPALSGSYGCTPQSLPKFWHPSHE--LLRENGFTQQV-------YHKYRRRCLNERKRL 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	24/77 (31%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	24/191 (13%)
larp1b	XP_005158614.1	LARP_1_2	325..397	CDD:153403	24/76 (32%)
		DM15	843..883	CDD:128927	7/27 (26%)
		DM15	884..922	CDD:128927
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900