DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and larp6b

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001082877.1	Gene:	larp6b / 565767	ZFINID:	ZDB-GENE-041008-244	Length:	471	Species:	Danio rerio

Alignment Length:	427	Identity:	117/427 - (27%)
Similarity:	194/427 - (45%)	Gaps:	128/427 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 PSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRVRQLTREWKVVGDAV 341
            |::::..:|...:|.|.|:|::..||||||||:|||.|:|||||::|||::|.|||:|:.. .|.
Zfish    57 PNDDVTQQIATQLENYLSDENLSDDAFLLKHVQRNKMGYVSLKLLTSFKKIRDLTRDWRTT-LAA 120

  Fly   342 RRKSRKIELNDVGTKVRRIEPLPSFDETMP-SRTIVACDL--------------PLDKLTI-EKV 390
            .|.|.::|:|::||||||..|:|.:...:| |:.::|.:.              .:::|.| |..
Zfish   121 ARTSPQLEVNEMGTKVRRRTPVPDWLLCIPTSKLLLAWNFLDGAGPVKEKFESPGVEQLGIMEAA 185

  Fly   391 SDLFSPCGEIALIRILKPGMAIPVDVRQFMNKYPELQQKECALVEYLESSSARDARHLNGPFQVY 455
            ..:|||.|.|:.:|||:||..||.:::::..|:.||.:|.||:|||         .:|.|..:.:
Zfish   186 MRVFSPYGTISSLRILRPGKEIPAELKRYTKKHLELGRKVCAVVEY---------EYLEGARKAF 241

  Fly   456 EMVAPKKKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRG----GSFSG-----HETVPDLRF 511
            |.:..:::.|.:...:.:..                   |||    |...|     .|...|:..
Zfish   242 EALKVEEQQGGRGICVVLLG-------------------SRGTRKPGCSQGLVDEEQEDCIDIDV 287

  Fly   512 KLKR--------------------NNSDFQPSYYQQT-----------GP-------SYHANPYQ 538
             |||                    :.|||.|:..:..           .|       ::.::||:
Zfish   288 -LKRPDRKARQFVYSLEDSAVCSSSESDFAPASPRPNRRVSRPQALYGSPLAIPRVSTFRSDPYR 351

  Fly   539 HYQPRGS-IGNQNQEVGPNGFFGYGPRRYSNTSTISANTAAALGDVSPISSAVNSGG-------- 594
            :  |.|| :|:..|           ||:....|.:::..|     ..|.||..:..|
Zfish   352 N--PLGSPVGSPLQ-----------PRKLFPCSHVTSPLA-----THPFSSTPSGAGTSFKYKAS 398

  Fly   595 ---NPMVSGISS---LQRRLSNCSEQNYTPEVNPSMS 625
               :|...|.:|   :|||.:  :.|...||:..|||
Zfish   399 GELSPDDLGFTSSPWVQRRKN--AAQVIQPEMASSMS 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	39/76 (51%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	29/113 (26%)
larp6b	NP_001082877.1	LARP_6	62..138	CDD:153402	39/76 (51%)
		RRM_SF	153..261	CDD:388407	29/116 (25%)
		SUZ-C	445..459	CDD:372374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596350
Domainoid	1	1.000	73	1.000	Domainoid score	I9211
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005698
OrthoInspector	1	1.000	-	-		otm25030
orthoMCL	1	0.900	-	-		OOG6_120975
Panther	1	1.100	-	-	O	PTHR22792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.700