DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Achl and larp

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	124/596 - (20%)
Similarity:	196/596 - (32%)	Gaps:	202/596 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 IPSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRVRQLTREWKVVGDA 340
            :.:..:...|...||:|||.:::..|.||.:  :.:.||::.:.|::||.||..||.:..|:.:|
  Fly   724 LDANSIKEAIKKQVEYYFSVDNLTGDFFLRR--KMDPEGYIPVTLIASFHRVLALTTDVAVIVNA 786

  Fly   341 VRRKSRKIELNDVGTKVRR--------IEPLPSFDETMPSRTIVACDLPLDKL-------TIEKV 390
            : ::|.|:||.: |.|||.        |..:|..:|..|.   ....|..::|       .:|:.
  Fly   787 I-KESDKLELFE-GYKVRTKTTPTTWPITEVPEVNEGEPK---AIGTLEQEQLEQNDGQEKLEEQ 846

  Fly   391 SDLFSPCGEIALIRILKPGMAIPVD--VRQFMNKYPE-LQQKE----------------CALVEY 436
            ::..||...:......||..:||..  .|...|..|: ||.|:                .||.:.
  Fly   847 TEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQ 911

  Fly   437 LESSSARDARHLNGPFQVYEMVAPKKKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRGGSFS 501
            :|..:|..|.||:|   :.|.|.||.
  Fly   912 VEGGAAELAGHLSG---LAESVKPKS--------------------------------------- 934

  Fly   502 GHETVPDLRFKLKRNNSDFQPSYYQQTGPSYHANPYQHYQPRGSIGNQNQEVG-----PNGFFGY 561
              .:.||     |||                          ..|.||......     |.|.:..
  Fly   935 --TSTPD-----KRN--------------------------AASAGNGAGSAAALVAEPEGIWKE 966

  Fly   562 GPRRYSNTSTISAN-TAAALGDVSPISSAVNSGGNPMVSGISSLQRRLSNCSEQNYTPEVNPSMS 625
            ..|| |.|:.|..| |........|:|..:|:..:              |....|.:.:...|.:
  Fly   967 VKRR-SKTNAIKENATTPPQQQQPPLSQTLNNNND--------------NVKTNNTSSKSKSSSN 1016

  Fly   626 RRASNCSETGGVPQRRDSNCSESCPCSRRVSDFAQTTDTSYRKTSVCSNGSCPGNNQNQERRFSN 690
            ...||.|.:..|           |..:...|...:.|    .||:..|..:...||     ...:
  Fly  1017 NAPSNASSSATV-----------CVTTNNASSATKAT----TKTTTTSTATTTTNN-----NIKS 1061

  Fly   691 GSMQFERTFSNASESSGFYRRPSNDFNIEREPIQ-------TDQLVGGGGGGYQVWPRRYSNNFQ 748
            |:..:.:|.|.:|..:.  ..||...:.|:|.:.       .|.|..|.|         ..|||
  Fly  1062 GNAAYSKTHSKSSSKTA--APPSAQCHAEKEELDFQFDEELMDPLPPGTG---------RINNF- 1114

  Fly   749 QLSSKLAAYDNAQY---------------IGGRRISTDSGYDRRCSFGSEGFEGSPRSRTGSFLS 798
              :...:..|.:.|               :|  |.....||||...|.|       |::....|.
  Fly  1115 --TENFSDDDESDYEFADRDINKLLIVAQVG--RAPKHEGYDRTADFTS-------RTKITQDLE 1168

  Fly   799 NYKHGGGDGYD 809
            |..:.|...|:
  Fly  1169 NIINDGLVNYE 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	27/76 (36%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	27/124 (22%)
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	27/76 (36%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930