DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and LARP7

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001357903.1	Gene:	LARP7 / 51574	HGNCID:	24912	Length:	595	Species:	Homo sapiens

Alignment Length:	388	Identity:	90/388 - (23%)
Similarity:	164/388 - (42%)	Gaps:	70/388 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 QEKEQEVPVHQEQDTEPQGPNEIDTLDPSLIPSEELAAEITDAVEFYFSNESILKDAFLLKHVRR 310
            |||     |.:|:.||.:  .|::....|.:  :::.|:|...|:|:|.:.::.||.||.:.:.:
Human     8 QEK-----VMEEESTEKK--KEVEKKKRSRV--KQVLADIAKQVDFWFGDANLHKDRFLREQIEK 63

  Fly   311 NKEGFVSLKLVSSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIEPLPSFDETMPSRTI 375
            :::|:|.:.|:.||.::::||.:.|::..|: |.|..:||:..||::||.:||....:....||:
Human    64 SRDGYVDISLLVSFNKMKKLTTDGKLIARAL-RSSAVVELDLEGTRIRRKKPLGERPKDEDERTV 127

  Fly   376 VACDLP--LDKLTIEKVSDLFSPCGEIALIRILKPGMAIPVDVRQFMNKYPELQQKECA--LVEY 436
            ....||  ::...||:|   |..||.:..|.|  |......|.:.|  .:.|.:.||.|  .:|:
Human   128 YVELLPKNVNHSWIERV---FGKCGNVVYISI--PHYKSTGDPKGF--AFVEFETKEQAAKAIEF 185

  Fly   437 LESSSARDARH--------LNGPFQVYEMVAPKKKTGKKAAVIQIAAPVARMVENYRYYNDANYE 493
            |.:......|.        .|.|.....:|..|||..||..               |...:.|.:
Human   186 LNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKG---------------RMKKEDNIQ 235

  Fly   494 RSRGGSFSGHETVPDLRFKLKRNNSDFQPSYYQQTGPSYHANPYQHYQPRGSIGNQNQEVGPNGF 558
            .......:.:.::.    |:||:....:.|..:.|.|....:..:..:.|.. .:...||..
Human   236 AKEENMDTSNTSIS----KMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVE-ASSLPEVRT--- 292

  Fly   559 FGYGPRRYSNTSTISANTAAALGDVSPISSAVNSGGNPMVSGISSLQRRLSNCSEQNYTPEVN 621
               |.|:.|     |:..|.:|...|.:...:.          ..:.:..|..|::|..|.:|
Human   293 ---GKRKRS-----SSEDAESLAPRSKVKKIIQ----------KDIIKEASEASKENRAPCLN 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	24/76 (32%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	30/110 (27%)
LARP7	NP_001357903.1	LARP_7	30..111	CDD:153401	24/83 (29%)
		RRM	<117..300	CDD:223796	44/220 (20%)
		RRM1_LARP7	126..205	CDD:240736	21/85 (25%)
		RRM_3	467..565	CDD:370115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810