DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and Larp6

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001101624.1	Gene:	Larp6 / 315731	RGDID:	1308414	Length:	492	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	138/482 - (28%)
Similarity:	217/482 - (45%)	Gaps:	113/482 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 LTMKKEKEVEPPQEKEQEVPVHQEQDT--------------EPQ----------GPNEIDTLDPS 274
            :.:::.::||..:|.::........||              ||.          |.|:.:.|:|.
  Rat    20 VAIQEAEDVEDLEEDDEGTSARAAGDTARYLSPGWGSASEEEPSRGHSSATTSGGENDREDLEPE 84

  Fly   275 -LIPSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRVRQLTREWKVVG 338
             ..|.|||..::.|.:|||||:|::.|||||||||||||.|:||:||::|||:|:.|||:|:...
  Rat    85 WKPPDEELIRKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTA 149

  Fly   339 DAVRRKSRKIELNDVGTKVRRIEPLPSF-DETMPSRTIVACDL------------PLDKLTIEKV 390
            .|: :.|..:|||:...||||..|:|.| :|.:||:.::..||            |.:....|||
  Rat   150 HAL-KYSVTLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLHLSPKLWSLATPPKNGRVQEKV 213

  Fly   391 SD----LFSPCGEIALIRILKPGMAIPVDVRQFMNKYPELQQKECALVEYLESSSARDARHL--- 448
            .:    ||...|.|:.:||||||..:|.|:|:..::|.::..:|||:||:.|..:|..|...
  Rat   214 MEYLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVDAAIKAHEFMAT 278

  Fly   449 ------NGPFQVYEMVAPKKKTGK-------KAAVIQIAAPVARMVENYRYYNDANYERSRGGSF 500
                  |....:..|..||||..|       .||..:::..:.:.||..:|..|    .|...|.
  Rat   279 ESQGKENMKAVLIGMRPPKKKPLKDKNHEDEPAAGTRLSRSLNKRVEELQYMGD----ESSANSS 339

  Fly   501 SGHETVPDLRFKLKRN--NSDFQPSYYQQTGPSYHANP--------------YQHYQPRGSIGNQ 549
            |..|:.|......:|:  ::...||.:|....|.:|:|              .....|....|..
  Rat   340 SDPESNPTSPMAGRRHVASNKLSPSGHQNIFLSPNASPCSSPWSSPLAQRKGVSRKSPLAEEGRL 404

  Fly   550 NQEVGPNGFFGYGPRR---YSNTSTISANTAAALGDVSPISSAVNSGGNPMVSGISSLQRRLSNC 611
            |....|..|     |:   ||:.|:|:.:                  |:|.|.     :||.:..
  Rat   405 NFSTSPEIF-----RKCMDYSSDSSITPS------------------GSPWVR-----RRRQAEM 441

  Fly   612 SEQNYTPEVNPSMSRRASNCSETGGVP 638
            ..|..:|..:|.:||:.....   |:|
  Rat   442 GTQEKSPGASPLLSRKMQTAD---GLP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	40/76 (53%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	37/130 (28%)
Larp6	NP_001101624.1	LARP_6	93..169	CDD:153402	40/76 (53%)
Larp6	NP_001101624.1	RRM_LARP6	184..292	CDD:240735	29/107 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8541
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005698
OrthoInspector	1	1.000	-	-		oto95778
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3569
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.870