DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Achl and LARP1

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_291029.2	Gene:	LARP1 / 23367	HGNCID:	29531	Length:	1096	Species:	Homo sapiens

Alignment Length:	1078	Identity:	215/1078 - (19%)
Similarity:	347/1078 - (32%)	Gaps:	372/1078 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AGAEGHTFLVSP---VDP--TPILAPILTAVPVMKAPDSPASMDKTKEMEELDDEQPSCSSQAVV 78
            |||....|:.:|   |:|  ...|.|:||.|.....|:..|               |:...:|.|
Human   109 AGAGRRDFVEAPPPKVNPWTKNALPPVLTTVNGQSPPEHSA---------------PAKVVRAAV 158

  Fly    79 P--------------LSSSLPCKLLRMHARRSAQALLHQMESMDSQLGSSNGSTSEDTSPSAPPM 129
            |              ::...|.::    |.:|.|...|:.:                .:...||.
Human   159 PKQRKGSKVGDFGDAINWPTPGEI----AHKSVQPQSHKPQ----------------PTRKLPPK 203

  Fly   130 SPTDHQLVDVGMGSSIGD-----SDESSEE--GDE---------------LKPLAVD-NHIIAEV 171
            .....|  :.|.||...:     ||||.||  |||               ..||.:| ...:...
Human   204 KDMKEQ--EKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPRE 266

  Fly   172 DLTERQTTPPAVLS-EANLEKFRKHQMDNIYLHPNFTLDASPPPAVAPANSP---------VLEA 226
            .|..|.|.||.... .||..:.:..:      ...:...|.|.||..|...|         ....
Human   267 KLASRPTRPPEPRHIPANRGEIKGSE------SATYVPVAPPTPAWQPEIKPEPAWHDQDETSSV 325

  Fly   227 K-----------------------------RTHRSF-LTMKKEKEVEPPQEKEQEVPVHQEQDT- 260
            |                             |||..: ...:|...||.|:     .|.:....|
Human   326 KSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPR-----TPKYMNNITY 385

  Fly   261 --EPQGPNEIDTLDPSLIPSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSS 323
              :.....|:.::|..|     |...|...:|:|||.:::.:|.||.:  :.:.:||:.:.|::|
Human   386 YFDNVSSTELYSVDQEL-----LKDYIKRQIEYYFSVDNLERDFFLRR--KMDADGFLPITLIAS 443

  Fly   324 FKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIE-----PLPSF----------------- 366
            |.||:.||.:..::..|: :.|:.:|:  |..||||.|     |||..
Human   444 FHRVQALTTDISLIFAAL-KDSKVVEI--VDEKVRRREEPEKWPLPPIVDYSQTDFSQLLNCPEF 505

  Fly   367 ---------DETMPSRTIVACDLPLDKLTIEKVSDLFS-PCGEIALIRIL------------KPG 409
                     .|:.|........:|   ...|:||:|.: |.|..|.:..|            :|.
Human   506 VPRQHYQKETESAPGSPRAVTPVP---TKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPS 567

  Fly   410 MAIP-----------------VDVRQFMNK-YPELQQKECALVEYLESSSAR------------- 443
            .|.|                 :..:|.|:| ..|.::.:....|.:|....|
Human   568 PARPKKSEESRFSHLTSLPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEESD 632

  Fly   444 ---DARHLNGPFQV-----YEMVAP-KKKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRGGS 499
               |.|.:|....|     |....| ..:||...:..:::|.:|:::.:..:|    ||:
Human   633 YEIDDRDVNKILIVTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFY----YEQ----- 688

  Fly   500 FSGHETVPDLRFKLKRNNSDFQPSYYQ--QTGPSY------HANPYQHYQPRGSIGNQNQEVGPN 556
                    ||..:      .|:|.|.|  |...::      ....:....|...: :.||||.|
Human   689 --------DLWAE------KFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPV-DPNQEVPP- 737

  Fly   557 GFFGYGPRRYSNTSTISANTAAALGDVSPISSAVNSGGNPMVSGISSLQRRLSNCSEQNYTPEVN 621
                 ||.|:....| .|......|...|                |::.|.|...     .||
Human   738 -----GPPRFQQVPT-DALANKLFGAPEP----------------STIARSLPTT-----VPE-- 773

  Fly   622 PSMSRRASNCSETGGVPQRRDSN-CSESCPCSRRVSDFAQTTDTSY---RKTSVCSN-------G 675
             |.:.|.:....|...||.:||: .|...|..:.    .:|.|...   |||...||       |
Human   774 -SPNYRNTRTPRTPRTPQLKDSSQTSRFYPVVKE----GRTLDAKMPRKRKTRHSSNPPLESHVG 833

  Fly   676 SCPGNNQNQERRFSNGSMQFERT-----FSNASESSGFYRRPSNDF------------NIEREPI 723
            ....:.:::.|..|..|...|.|     :....:|...::.||::.            ...|..:
Human   834 WVMDSREHRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCL 898

  Fly   724 QTDQLVGGGGGG-----YQVWP--------RRYSNNFQQLSSKLAAYDNAQYIGGRRISTDSGYD 775
            ...:.:|.|...     ::.|.        ::....|:||     |.::|:  .|.|      |.
Human   899 NERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQL-----ALEDAK--EGYR------YG 950

  Fly   776 RRCSFGSEGFEGSPRSRTGSF-------LSNYKHG---GGDGYDGQPRSRTGSFLDGSPRSRS-- 828
            ..|.|....:....:.|...|       :.:|:.|   |.:.:....:......||..|:.:.
Human   951 LECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYL 1015

  Fly   829 GSFAQRAAESLVRTPMGPDGSK--------GFGQRARK 858
            |.| :|..:..|..|||.:|:.        |.|...||
Human  1016 GKF-RRLEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	23/76 (30%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	27/151 (18%)
LARP1	NP_291029.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..356		55/289 (19%)
		Required for interaction with PABPC1. /evidence=ECO:0000269\|PubMed:29244122	77..573		111/524 (21%)
		LARP_1	404..476	CDD:153406	23/76 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..598		16/89 (18%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000269\|PubMed:29244122	574..1096		104/552 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..861		28/129 (22%)
		Interaction with mRNA. /evidence=ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:26206669	873..1023		27/163 (17%)
		DM15	885..925	CDD:128927	4/39 (10%)
		DM15	926..964	CDD:128927	10/50 (20%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000269\|PubMed:28379136, ECO:0007744\|PDB:5V87	956..999		5/42 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1026..1096		9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900