DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and Larp1b

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001035489.2	Gene:	Larp1b / 214048	MGIID:	1914604	Length:	541	Species:	Mus musculus

Alignment Length:	423	Identity:	85/423 - (20%)
Similarity:	146/423 - (34%)	Gaps:	127/423 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PVDPTPILAPILTAVPVMKAPDSPASMDKTKEMEELDDEQPSCSSQAVVPLSSSLPCKLLRMHAR 94
            |..|.|.|.|.....|...|.:.||:..        .:::|........|.:..||..|..:...
Mouse   113 PPPPPPPLPPPAPRDPPEDAREDPAAAG--------PEDKPPPPPPKGNPWTKKLPQHLSTVGTG 169

  Fly    95 RSAQALLHQMESMDSQLGSSN----GSTSEDTSPSAPPMS-----PTDHQLVDVGMGSSIGD--- 147
            ..:.|    .:|.:::|.|..    |......|..|...|     ||..:||:.|..|.|..
Mouse   170 VPSPA----QDSPEAELSSPKIIKAGKLKTKKSNKASDFSDMANWPTPGELVNTGSQSVINQGNK 230

  Fly   148 ---------------SDESSEEGDELKPLAVDNHIIAEVDLTERQTTPPAVLSEANLEKFRKHQM 197
                           |:..|:|..|           |::|......:.....|.:..::..||:.
Mouse   231 KPQIRKEKEEKIEKRSNSESKENRE-----------AKLDGPTENISEDEAQSSSQRKRANKHKW 284

  Fly   198 DNIYLHPNFTLDASPPPAVAP-----------ANSPVLEAKRTHRSFLTMKKEKEVEPPQEKEQE 251
            ..::|.     |..|.....|           ||.|.    .::|...|....:|.|...::::.
Mouse   285 VPLHLD-----DVRPDSQERPGSRNSSRCQPEANKPT----HSNRKSDTRSWRREREKRDDQDEV 340

  Fly   252 VPVHQE----------------------------------------QDTEPQGPNEIDT------ 270
            ..|..|                                        :.||.....|::|
Mouse   341 SSVRSEGGTIRGSTRGRGRGRGRGRGRGRGNPRLNFDYSYGYREPGERTEQPFSTELNTSMMYYY 405

  Fly   271 ---LDPSLIPSEE--LAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRVRQL 330
               ....:.|.||  |...|...:|:|||.|::.:|.||.:  :.:::||:.:.|::.|.||:.|
Mouse   406 DDGTGVRVYPVEETLLKEYIKRQIEYYFSTENLERDFFLRR--KMDEQGFLPISLIAGFHRVQAL 468

  Fly   331 TREWKVVGDAVRRKSRKIELNDVGTKVR-RIEP 362
            |....::.:|: :.|.::|:  |..|:| :|||
Mouse   469 TTNLNLILEAL-KDSTEVEI--VDEKMRKKIEP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	23/77 (30%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735
Larp1b	NP_001035489.2	LARP_2	422..494	CDD:153407	22/76 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900