DRSC/TRiP Functional Genomics Resources

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Protein Alignment Achl and Larp4

DIOPT Version :9

Sequence 1:NP_001286419.1 Gene:Achl / 36605 FlyBaseID:FBgn0033936 Length:867 Species:Drosophila melanogaster
Sequence 2:NP_001271452.1 Gene:Larp4 / 207214 MGIID:2443114 Length:720 Species:Mus musculus


Alignment Length:474 Identity:99/474 - (20%)
Similarity:170/474 - (35%) Gaps:137/474 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 PAVAPANSPVLEAKRTHRSFLT--------------MKKEKEV--EPPQEKEQE-VPVHQEQDTE 261
            |:..|..:||.|.. .|.:..|              |.||.||  .|..|..:. ..|.:..|..
Mouse    26 PSGNPDGTPVTEPS-WHETAATSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGM 89

  Fly   262 PQGPN-------EIDTLDPSLIPSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLK 319
            ..||.       ::.....|.|.:|:|...:...:||.||.|::.||.:|:..:  :.:.||.:.
Mouse    90 ILGPEDLSYQLYDVSGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQM--DSDQFVPIW 152

  Fly   320 LVSSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIEPLPSFDETMPSRTIVACDLPLDK 384
            .|::.:.:::||....::.: |.|.|..:::::.|.|||     ||....:    ::..::| :.
Mouse   153 TVANMEEIKKLTTNTDLILE-VLRSSPMVQVDEKGEKVR-----PSHKRCI----VILREIP-ET 206

  Fly   385 LTIEKVSDLF--SPCGEIALIRILKPGMAIPVDVRQFMNKYPELQQKECALVE----YLESSSAR 443
            ..:|:|..||  ..|.::.                            .|....    |:...|..
Mouse   207 TPVEEVKALFKNENCPKVI----------------------------SCEFAHNSNWYITFQSDT 243

  Fly   444 DARHLNGPFQVYEMVAPKKKTGK-KAAVIQIAAPVARMVEN-YRYYNDANYERSRGGSFSGHETV 506
            ||:      |.::.:..:.||.: |..:.:|.|......:| ||..:.:.|.:    ........
Mouse   244 DAQ------QAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYTQ----PIQTPTQY 298

  Fly   507 PDLRFKLKRNNSDFQPSYYQQTGPSYHANPYQHYQ------PRGSIGNQNQEVGPNGFFGYG--- 562
            |...|.....|.. |.|.|.....|:..:|..:::      |.||.        .|||...|   
Mouse   299 PSPVFMQPVYNPQ-QYSVYSLVPQSWSPSPAPYFETPLAPFPNGSF--------VNGFSSPGSYK 354

  Fly   563 ------------PR-------RYSNTSTISANTAAALGDVSPISSA-----VNSGGNPMVSGISS 603
                        |:       |.|:.|..|...:.:||| .|:|.:     ::...||.|:|   
Mouse   355 TNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGD-GPLSRSSSRIFLSERHNPTVTG--- 415

  Fly   604 LQRRLSNCSEQNYTPEVNP 622
                   ..||.|.|:..|
Mouse   416 -------QQEQTYLPKEAP 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AchlNP_001286419.1 LARP_6 282..359 CDD:153402 19/76 (25%)
RRM_LARP6 373..472 CDD:240735 15/105 (14%)
Larp4NP_001271452.1 Interaction with PABPC1. /evidence=ECO:0000250|UniProtKB:Q71RC2 13..22
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..56 7/30 (23%)
Interaction with the poly-A tract of mRNA. /evidence=ECO:0000250|UniProtKB:Q71RC2 108..300 47/242 (19%)
LARP_4 117..191 CDD:153404 20/81 (25%)
RRM_LARP4 196..272 CDD:241151 17/114 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..399 10/35 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..471
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..563
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..602
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..720
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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