DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Achl and LARP4

DIOPT Version :9

Sequence 1:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_011536131.1	Gene:	LARP4 / 113251	HGNCID:	24320	Length:	732	Species:	Homo sapiens

Alignment Length:	752	Identity:	137/752 - (18%)
Similarity:	249/752 - (33%)	Gaps:	235/752 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 LHPNFTLDASPPPAVAPAN---SPVLEAKRT--HRSFLT--MKKEKEVEPPQE--KEQEVPVHQE 257
            |:||    |.....:||.|   :||.....:  |....|  ...|...|..::  ||.||.....
Human    23 LNPN----AKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSS 83

  Fly   258 QDTEPQGPNEIDTLDPSLIPSEELAAEITDA--------------------VEFYFSNESILKDA 302
            .:|........::.|..::..|:|:.:|.|.                    :||.||.|::.||.
Human    84 CETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDL 148

  Fly   303 FLLKHVRRNKEGFVSLKLVSSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIEPLPSFD 367
            :|:..:  :.:.|:.:..|::.:.:::||.:..::.: |.|.|..:::::.|.|||     ||..
Human   149 YLISQM--DSDQFIPIWTVANMEEIKKLTTDPDLILE-VLRSSPMVQVDEKGEKVR-----PSHK 205

  Fly   368 ETMPSRTIVACDLPLDKLTIEKVSDLFSP--CGEIALIRIL------------------------ 406
            ..:    ::..::| :...||:|..||..  |.::......
Human   206 RCI----VILREIP-ETTPIEEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLRE 265

  Fly   407 -------KPGMAIPVDVRQFMNK------------YPELQQKECALVEYLESSSARDARHLNGPF 452
                   ||.||....:..|..|            :|...|.:.|...:::.        :..|.
Human   266 EVKTFQGKPIMARIKAINTFFAKNGYRLMDSSIYSHPIQTQAQYASPVFMQP--------VYNPH 322

  Fly   453 QVYEMVAPKKKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRGGSFSGHETVPDLRFKLKRNN 517
            |.|.:.:...::...........|:|.. .|..:.|..|    ..||:..:....::....::|.
Human   323 QQYSVYSIVPQSWSPNPTPYFETPLAPF-PNGSFVNGFN----SPGSYKTNAAAMNMGRPFQKNR 382

  Fly   518 SDFQPSYYQQTGPSYHAN-------------------PYQHYQPRGSIGNQNQ----------EV 553
            ...|   ::.:|.|.|:.                   |.:.:.|..: |:|.|          :|
Human   383 VKPQ---FRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTVT-GHQEQTYLQKETSTLQV 443

  Fly   554 GPNGFFGYGPR------------RYSNTSTISANTAAALGDVSPISSAVNSGGNPMVSGISS--- 603
            ..||.:|.|.|            |.|.....:|.:.|.......::|     ..|.:.|.||
Human   444 EQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTPKFDLLAS-----NFPPLPGSSSRMP 503

  Fly   604 ----LQRRLSNCSEQNYTPEVNPSMSRRASNCSETGGVPQRRDSNC--------SESCPCSRRVS 656
                |:.|:|:..:..|..:.|..::   .:|.    ||....:.|        |.|.||:..::
Human   504 GELVLENRMSDVVKGVYKEKDNEELT---ISCP----VPADEQTECTSAQQLNMSTSSPCAAELT 561

  Fly   657 DFA--------------------QTT----DTSYRKTSVCSNGSCPGNNQNQERRFSNGSMQFER 697
            ..:                    |||    ..|..|.|..|..|...||.|.....   ::|..|
Human   562 ALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPSRASTASPCNNNINAATAV---ALQEPR 623

  Fly   698 TFSNASESSGFYRRPSNDFNIEREPIQTDQLVGGGGGGYQVWPRRYSNNFQQLSSKLAAYDNAQY 762
            ..|.|....   :.|....::..:|:                        ::|.|.:.:....:.
Human   624 KLSYAEVCQ---KPPKEPSSVLVQPL------------------------RELRSNVVSPTKNED 661

  Fly   763 IGGRRISTDSGYDR---RCSFGSEGFEGS--PRSRTG 794
            .|....|.:..:::   |.|....||.|:  ||...|
Human   662 NGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAAG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	20/96 (21%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	19/143 (13%)
LARP4	XP_011536131.1	LARP_4	128..202	CDD:153404	19/81 (23%)
LARP4	XP_011536131.1	RRM_LARP4	207..283	CDD:241151	11/80 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900