DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sin1 and Mapkap1

DIOPT Version :9

Sequence 1:NP_610963.1 Gene:Sin1 / 36604 FlyBaseID:FBgn0033935 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_001011964.1 Gene:Mapkap1 / 296648 RGDID:1305363 Length:522 Species:Rattus norvegicus


Alignment Length:623 Identity:167/623 - (26%)
Similarity:273/623 - (43%) Gaps:173/623 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPT 65
            ||...|...:|:|||.|.:::|||||||.|::..|:.   |.|.......||     ...:...:
  Rat     1 MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVD---LEKTHPPSVPGD-----SGSEVQGS 57

  Fly    66 GGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEK 130
            .|.|.               .:|....:|:        |.|:|..:       |.||||||:||:
  Rat    58 SGETQ---------------GYIYAQSVDI--------TSSWDFGI-------RRRSNTAQRLER 92

  Fly   131 LDIAKRRAARIKSVNYQE---EVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQL 192
            |...::...:.|::.::|   :....|....|::|.|        |.:|.::       |.||.|
  Rat    93 LRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSL--------KEKPPSS-------GKQSIL 142

  Fly   193 TEQLAKSPKQAQNRFIEFARFDGTSQVG-MQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVI 256
            :.:|.:.|.|..|.|.|:::|||...|| ..||:|:|:|.:....||..|:.:..:|:|::|::|
  Rat   143 SVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLI 207

  Fly   257 GFVCYRTSLQYPDVPLK-SLQHYALYMTEDNDDME-DFPPLDNREPCSKFGFSQLTLAERRPLAP 319
            |.:|::.:.:..:..|. ::..|.|::.||:.::: ||||||:.||..|||||.|.|.|:     
  Rat   208 GLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEK----- 267

  Fly   320 VTRVDYHSQ-LGSK-------------SMTSVED-KTALSDAAVKAL------QNISLNGG---- 359
                 |.|. |.||             |:..|:: |..:.:..:|||      |.||   |    
  Rat   268 -----YSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKALKRRKGSQKIS---GPQYR 324

  Fly   360 ---TSDPGGGGG-----------------GGDSPHDNVKEYEKR--LLNHNDMLEAPMHRTFRLN 402
               .|:|..|..                 ...|..|.|.|.:.:  :....|||.:..:::|:::
  Rat   325 LEKQSEPNIGVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVS 389

  Fly   403 IIDKRFFKSDVTLGISGERIEIDQCKN----AKFWPQKKPVSTPIDFVAHCEILERRHLKALLRI 463
            :|.:..|.:||.|||||:::|||...|    .|||.::||:|...|.:..|::.|.:        
  Rat   390 MIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEK-------- 446

  Fly   464 WLKSNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHS-SGLFSSSNIRFKHYDFDT 527
                                                     ||.|: ..|...|:..:||..|::
  Rat   447 -----------------------------------------SPSHAVFKLTYLSSHDYKHLYFES 470

  Fly   528 DTHTAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKR 565
            |..|..:|..|:|.|||.|:|..|.::..|:.||..:|
  Rat   471 DAATVSEIVLKVNYILESRASTARADYFAQKQRKLNRR 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sin1NP_610963.1 SIN1 18..164 CDD:283156 35/148 (24%)
CRIM 189..316 CDD:293583 49/129 (38%)
SIN1_PH 394..545 CDD:293584 38/155 (25%)
Mapkap1NP_001011964.1 Interaction with NBN. /evidence=ECO:0000250 2..267 94/317 (30%)
Interaction with MAP3K2. /evidence=ECO:0000250 2..184 65/234 (28%)
SIN1 18..129 CDD:398858 35/148 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..59 4/25 (16%)
CRIM 140..266 CDD:407188 47/125 (38%)
PH_Avo1 383..490 CDD:270139 39/155 (25%)
Interaction with ATF2. /evidence=ECO:0000250 468..522 16/41 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343370
Domainoid 1 1.000 94 1.000 Domainoid score I7288
eggNOG 1 0.900 - - E1_KOG3739
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11473
Inparanoid 1 1.050 174 1.000 Inparanoid score I3980
OMA 1 1.010 - - QHG46995
OrthoDB 1 1.010 - - D1492466at2759
OrthoFinder 1 1.000 - - FOG0004857
OrthoInspector 1 1.000 - - otm44444
orthoMCL 1 0.900 - - OOG6_100876
Panther 1 1.100 - - LDO PTHR13335
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5980
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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