Protein Alignment CG10104 and Bace2

DIOPT Version :9

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_062390.3
• Gene: Bace2 / 56175
• MGIID: 1860440
• Length: 514
• Species: Mus musculus
• Alignment Length: 481
• Identity: 113/481 - (23%)
• Similarity: 183/481 - (38%)
• Gaps: 153/481 - (31%)

  Fly     2 WLL---VSLLPVLFILPVQF----QHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLR--LKY 57
            |||   .:|.|..|.||:|.    .|..|.      ||....|.. .|.:.|.:.::.:|  ..:
Mouse    16 WLLSAVPALAPAPFTLPLQVARATNHRASA------VPGLGTPEL-PRADGLALALEPVRATANF 73

  Fly    58 AEEVSHFRGEWNSAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVA 122
            ...|.:.:|:....             |:..:.||||||..:::.||||||..|..|.
Mouse    74 LAMVDNLQGDSGRG-------------YYLEMLIGTPPQKVQILVDTGSSNFAVAGAP------- 118

  Fly   123 CRVH---NRYF-AKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRV-----AGLEIRDQTFAEAT 178
               |   :.|| ::.|:::..:|....:.|..||.:||:..|.|.:     :...:...|..|:.
Mouse   119 ---HSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE 180

  Fly   179 E--MPGPIFLAAKFDGIFGLAYRSISMQRIKPP------FYAMMEQGLLTKPIFSVYLSRNG--- 232
            .  :||     .|::||.||||.:::    ||.      |.:::.|..: ..|||:.:...|
Mouse   181 NFFLPG-----IKWNGILGLAYAALA----KPSSSLETFFDSLVAQAKI-PDIFSMQMCGAGLPV 235

  Fly   233 ---EKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVI--RNLEL-CQQ--GCEVIIDT 289
               ..:||::..||..|..|.|:..|..:....|:|:::....|  :||.| |::  ..:.|:|:
Mouse   236 AGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDS 300

  Fly   290 GTSFLALP---YDQAI-------LINESIGG--------------TPSSFGQFLVPCDSVPDLPK 330
            ||:.|.||   :|..:       ||.|...|              ||.::            .||
Mouse   301 GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAY------------FPK 353

  Fly   331 ITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLP---------------------SPSGP 374
            |:                   ||......|.:|....||                     |.|..
Mouse   354 IS-------------------IYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTN 399

  Fly   375 LWILGDVFLGKYYTEFDMERHRIGFA 400
            ..::|...:..:|..||..:.|:|||
Mouse   400 ALVIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	5/25 (20%)
		pepsin_retropepsin_like	76..400	CDD:299705	92/396 (23%)
		Asp	84..402	CDD:278455	94/390 (24%)
Bace2	NP_062390.3	beta_secretase_like	85..446	CDD:133140	94/405 (23%)
		Asp	88..425	CDD:278455	92/387 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810