DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10104 and PGA5

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_055039.1	Gene:	PGA5 / 5222	HGNCID:	8887	Length:	388	Species:	Homo sapiens

Alignment Length:	402	Identity:	157/402 - (39%)
Similarity:	223/402 - (55%)	Gaps:	22/402 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLLVSLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRG 66
            |||:..|..|            .:..:|:|||.|..|.|....:.|:..|.|:.........:..
Human     3 WLLLLGLVAL------------SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFP 55

  Fly    67 EWN--SAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRY 129
            :|.  :.|...||.||||.:|||.|.||||.|.|.|:||||||||||||..|:|  :||..|||:
Human    56 QWEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSS--LACTNHNRF 118

  Fly   130 FAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIF 194
            ..:.|:::|...:..:|.||:||::|.|..|||:|.|:...:|.|..:...||.....|.||||.
Human   119 NPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGIL 183

  Fly   195 GLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEKDGGAIFFGGSNPHYYTGNFTYVQVS 259
            ||||.|||.....|.|..:..|||:::.:||||||.: :|.|..:.|||.:..||||:..:|.|:
Human   184 GLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD-DKSGSVVIFGGIDSSYYTGSLNWVPVT 247

  Fly   260 HRAYWQVKMDSAVIRNLEL-CQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCD 323
            ...|||:.:||..:....: |.:||:.|:|||||.|..|......|...||.:.:|.|..:|.|.
Human   248 VEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCS 312

  Fly   324 SVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYT 388
            ::..||.|.||:.|.::.:....|    |.|....|.|.|..:::|:.||.||||||||:.:|:|
Human   313 AISSLPDIVFTINGVQYPVPPSAY----ILQSEGSCISGFQGMNVPTESGELWILGDVFIRQYFT 373

  Fly   389 EFDMERHRIGFA 400
            .||...:::|.|
Human   374 VFDRANNQVGLA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	9/25 (36%)
		pepsin_retropepsin_like	76..400	CDD:299705	139/324 (43%)
		Asp	84..402	CDD:278455	134/318 (42%)
PGA5	NP_055039.1	A1_Propeptide	17..45	CDD:285240	10/27 (37%)
		pepsin_A	66..386	CDD:133145	140/327 (43%)
		Asp	75..387	CDD:278455	134/318 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930