Protein Alignment CG10104 and bace2

DIOPT Version :10

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: XP_009289748.1
• Gene: bace2 / 449818
• ZFINID: ZDB-GENE-041010-68
• Length: 503
• Species: Danio rerio
• Alignment Length: 463
• Identity: 115/463 - (24%)
• Similarity: 184/463 - (39%)
• Gaps: 123/463 - (26%)

  Fly    11 LFILPVQF--QHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGEWNSAVK 73
            |.:|.:.|  .|.|      :::||..|..   :| ...:::| ||.....|.:...|   .::.
Zfish     6 LLLLSLTFWKSHSV------FKIPLNIFAG---KF-NASVQLD-LRPLQKNEAAAKSG---LSLA 56

  Fly    74 STP--LSNYLD----------AQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVH 126
            |.|  :.|:||          ..|:..:.||||.||..::.||||||.          .||...|
Zfish    57 SDPAGIVNFLDMINNLKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNF----------AVAAAAH 111

  Fly   127 ---NRYFAKR-STSHQVRGDHFAIHYGSGSLSGFLSTD------------TVRVAGLEIRDQTFA 175
               ..||.:. |:::|......|:.|..|...|.|.||            |:.:|.:...:..|
Zfish   112 PYITHYFNRALSSTYQSTERAVAVKYTQGEWEGELGTDLITIPEGPSGAITINIAAILTSEGFF- 175

  Fly   176 EATEMPGPIFLAAKFDGIFGLAYRSISM--QRIKPPFYAMMEQ-GLLTKPIFSVYL-------SR 230
                :||     ..:.||.||||..::.  ..::|.|.:::.| |:  ..:||:.:       |.
Zfish   176 ----LPG-----INWQGILGLAYPLLARPDPSVEPFFNSVVRQTGI--PDVFSLQMCGAGVPAST 229

  Fly   231 NGEKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVI--RNLEL-CQQ--GCEVIIDTG 290
            .|:..||::..||..|..:.|...|..|....|:||::....:  :||.| |::  ..:.|:|:|
Zfish   230 TGDPAGGSLIMGGVEPTLHRGPIWYTPVLEEWYYQVEVLKLEVGDQNLNLDCKEYNSDKAIVDSG 294

  Fly   291 TSFLALPYDQAILINESIGGT----PSSFGQFLVPCDSVPDLPKITFTLGGR---RFFLESHEYV 348
            |:.|.||.:....:.::|..|    ..|.|.|        |..|:...:.|.   |||.:.
Zfish   295 TTLLRLPANVFTAVVDTIMQTSLIDDFSAGFF--------DGTKLACWMRGESPWRFFPKV---- 347

  Fly   349 FRDIYQDRRICSSAFIAVDLP---------------------SPSGPLWILGDVFLGKYYTEFDM 392
              .||......|.:|....||                     |||....::|...:..:|..||.
Zfish   348 --SIYLRGTNTSQSFRITILPQLYIQPVTDIDGTLDCFRFGISPSANGLVIGATVMEGFYVIFDR 410

  Fly   393 ERHRIGFA 400
            .:.|:|||
Zfish   411 AQKRVGFA 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	pepsin_retropepsin_like	76..400	CDD:472175	98/394 (25%)
bace2	XP_009289748.1	beta_secretase_like	77..439	CDD:133140	96/378 (25%)