DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and napsa

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001005701.1	Gene:	napsa / 448214	XenbaseID:	XB-GENE-947098	Length:	402	Species:	Xenopus tropicalis

Alignment Length:	386	Identity:	173/386 - (44%)
Similarity:	239/386 - (61%)	Gaps:	26/386 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGEWNSAVKS--------TPLSNYLDAQ 84
            |.|:||::|||.|.....                |..:.|:|.|.|.        ..|:||||||
Frog    18 LIRIPLKKFPSIRRTLSD----------------SMTKEEFNGATKEFLKQQTIPEKLTNYLDAQ 66

  Fly    85 YFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHYG 149
            |:|.|.||||||.|.||||||||||||||..|:....||.:|.:|.:|.|:::|.....|||.||
Frog    67 YYGEIFIGTPPQKFAVIFDTGSSNLWVPSIKCSFFDFACWLHKKYRSKDSSTYQQNNTEFAIQYG 131

  Fly   150 SGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAMM 214
            :||||||||.|||.|..:::.:||||||.:.||.:|:.|.||||.|:.|.:||:..:.|.|..||
Frog   132 TGSLSGFLSQDTVTVGSIDVANQTFAEAVKQPGIVFVFAHFDGILGMGYPNISVDGVVPVFDNMM 196

  Fly   215 EQGLLTKPIFSVYLSRNG-EKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVIRN-LE 277
            ||.||.:.:||.||||:. ...||.:..||::|:||||:|.|:.|:..||||:|.|...:.| |.
Frog   197 EQKLLEENVFSFYLSRDPMAMVGGELVLGGTDPNYYTGDFHYLNVTRMAYWQIKADEVRVANQLV 261

  Fly   278 LCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCDSVPDLPKITFTLGGRRFFL 342
            ||:.||:.|:|||||.:..|.::...::::||..|...|::.|.|..:..||.::|.|||..:.|
Frog   262 LCKGGCQAIVDTGTSLITGPREEIRALHKAIGAFPLFSGEYFVNCKRIQSLPTVSFILGGVAYNL 326

  Fly   343 ESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFADAR 403
            ...:||.:.......:|.|.|:.:|:..|:||||||||||:|:|||.||.:..|:|||.|:
Frog   327 TGEQYVLKISKFGHTLCLSGFMGLDIRPPAGPLWILGDVFIGQYYTVFDRDNDRVGFATAK 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	8/25 (32%)
		pepsin_retropepsin_like	76..400	CDD:299705	157/325 (48%)
		Asp	84..402	CDD:278455	153/319 (48%)
napsa	NP_001005701.1	A1_Propeptide	18..42	CDD:369623	9/39 (23%)
napsa	NP_001005701.1	pepsin_retropepsin_like	61..384	CDD:386101	156/322 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110