DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and ren

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_998025.1	Gene:	ren / 405786	ZFINID:	ZDB-GENE-040630-3	Length:	395	Species:	Danio rerio

Alignment Length:	381	Identity:	155/381 - (40%)
Similarity:	227/381 - (59%)	Gaps:	13/381 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LYRVPLRRFPSARHRFEKLGIR----MDRLRLKYAEEVSHFRGEWNSAVKSTPLSNYLDAQYFGP 88
            |:||.|::.||.|...:::.:.    :..:..|| :|.|...|     ...|||.||||.||||.
Zfish    21 LWRVKLKKMPSIRETLKEMSVTPAQVLSEIMPKY-QEPSPTNG-----TAPTPLINYLDTQYFGE 79

  Fly    89 ITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHYGSGSL 153
            |:||:|.|.|.|:|||||:||||||.:|:....||..||||.|.:|.:|...|..|:|.|.||::
Zfish    80 ISIGSPAQMFNVVFDTGSANLWVPSHSCSPLYTACFTHNRYDASKSLTHIFNGTGFSIQYASGNV 144

  Fly   154 SGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAMMEQGL 218
            .||||.|.|.|.|:.: .|.|||||.:|...|:.|||||:.|:.|.::::..|.|.|..:|.|.:
Zfish   145 RGFLSEDVVVVGGIPV-VQVFAEATALPAIPFILAKFDGVLGMGYPNVAIDGITPVFDRIMSQHV 208

  Fly   219 LTKPIFSVYLSRNGEK-DGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDS-AVIRNLELCQQ 281
            |.:.:||||.||:... .||.:..||::|:|:||.|.|:....:..|:|.|.. :|..::..|:.
Zfish   209 LKENVFSVYYSRDPTHIPGGELVLGGTDPNYHTGPFHYINTKEQGKWEVIMKGVSVGADILFCKD 273

  Fly   282 GCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCDSVPDLPKITFTLGGRRFFLESHE 346
            ||..:||||:|::..|.....::.::||....:.|.:.|.|:.|..||.:.|.|||:.:.|...:
Zfish   274 GCTAVIDTGSSYITGPASSISILMKTIGAVELAEGGYTVSCNVVRLLPTVAFHLGGQEYSLTDED 338

  Fly   347 YVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFADA 402
            |:.........||:..|.|:|:|.|:||:||||..|:.:||||||...:|||||.|
Zfish   339 YILWQSEFGEDICTVTFKALDVPPPTGPVWILGANFIARYYTEFDRGNNRIGFARA 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	7/29 (24%)
		pepsin_retropepsin_like	76..400	CDD:299705	139/325 (43%)
		Asp	84..402	CDD:278455	135/319 (42%)
ren	NP_998025.1	A1_Propeptide	23..>38	CDD:285240	6/14 (43%)
		renin_like	68..394	CDD:133154	140/326 (43%)
		Asp	75..394	CDD:278455	135/319 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20151
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120302
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.790