Protein Alignment CG10104 and BACE2

DIOPT Version :9

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 116/479 - (24%)
• Similarity: 181/479 - (37%)
• Gaps: 145/479 - (30%)

  Fly     2 WLL---VSLLPVLFILPVQFQHPVSCKLQLYRV----PLRRFPSARHRFEKLGIRMDRLRLKYAE 59
            |||   ..|.|..|.||::.....:      ||    |....|:.||        .|.|.|....
Human    16 WLLRAAPELAPAPFTLPLRVAAATN------RVVAPTPGPGTPAERH--------ADGLALALEP 66

  Fly    60 EVSHFRGEWNSAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACR 124
            .::...|..|.......|.......|:..:.||||||..:::.||||||.          .||..
Human    67 ALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNF----------AVAGT 121

  Fly   125 VH---NRYF-AKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRV-----AGLEIRDQTFAEATE- 179
            .|   :.|| .:||::::.:|....:.|..||.:||:..|.|.:     ....:...|..|:..
Human   122 PHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENF 186

  Fly   180 -MPGPIFLAAKFDGIFGLAYRSISMQRIKPP------FYAMMEQGLLTKPIFSVYLSRNG----- 232
             :||     .|::||.||||.:::    ||.      |.:::.|..:.. :||:.:...|
Human   187 FLPG-----IKWNGILGLAYATLA----KPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAG 241

  Fly   233 -EKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVI--RNLEL-CQQ--GCEVIIDTGT 291
             ..:||::..||..|..|.|:..|..:....|:|:::....|  ::|.| |::  ..:.|:|:||
Human   242 SGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGT 306

  Fly   292 SFLALP---YD-------QAILINESIGG--------------TPSSFGQFLVPCDSVPDLPKIT 332
            :.|.||   :|       :|.||.|...|              ||.|:            .|||:
Human   307 TLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSY------------FPKIS 359

  Fly   333 FTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLP---------------------SPSGPLW 376
                               ||......|.:|....||                     |||....
Human   360 -------------------IYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNAL 405

  Fly   377 ILGDVFLGKYYTEFDMERHRIGFA 400
            ::|...:..:|..||..:.|:|||
Human   406 VIGATVMEGFYVIFDRAQKRVGFA 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	7/29 (24%)
		pepsin_retropepsin_like	76..400	CDD:299705	95/396 (24%)
		Asp	84..402	CDD:278455	96/390 (25%)
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	96/392 (24%)
		Asp	92..430	CDD:278455	96/389 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810