DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10104 and Ctse

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_006249810.1	Gene:	Ctse / 25424	RGDID:	2446	Length:	398	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	156/408 - (38%)
Similarity:	238/408 - (58%)	Gaps:	23/408 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLVSLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLR------LKYAEEV 61
            |.|.||.:|.:...|.|.      .|:||||||..|.|.:....|...|..|      ::::|..
  Rat     4 LFVLLLLLLLLDLAQAQG------VLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESC 62

  Fly    62 SHFRGEWNSAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVH 126
            :..:|      .:.||.||||.:|||.::||:|.|.|.||||||||||||||..|.|.  ||:.|
  Rat    63 NVDKG------INEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSP--ACKAH 119

  Fly   127 NRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFD 191
            ..:...:|:::...|:||:|.||:|||:|.:..|.|.|.||.:..|.|.|:.:.||..|:.|:||
  Rat   120 PVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFD 184

  Fly   192 GIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEKDGGA-IFFGGSNPHYYTGNFTY 255
            ||.||.|.|:::..:.|.|..||.|.|:..|:||||||.:.:...|: :.|||.:|.:::|:..:
  Rat   185 GILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNW 249

  Fly   256 VQVSHRAYWQVKMDSAVIRN-LELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFL 319
            :.|:.:.|||:.:|...:.: :..|.:||:.|:|||||.:..|..:...:.|:||.||.. |::.
  Rat   250 IPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMD-GEYA 313

  Fly   320 VPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLG 384
            |.|.::..:|.:||.:.|..:.|....|:..|:....:.|.|.|..:|:..|:||||||||||:.
  Rat   314 VDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIR 378

  Fly   385 KYYTEFDMERHRIGFADA 402
            |:|:.||...:::|.|.|
  Rat   379 KFYSVFDRGNNQVGLAPA 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	11/25 (44%)
		pepsin_retropepsin_like	76..400	CDD:299705	133/325 (41%)
		Asp	84..402	CDD:278455	128/319 (40%)
Ctse	XP_006249810.1	A1_Propeptide	23..51	CDD:285240	12/27 (44%)
		Asp	79..396	CDD:278455	128/319 (40%)
		pepsin_retropepsin_like	80..395	CDD:299705	127/317 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860