DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10104 and Ren

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_036774.4	Gene:	Ren / 24715	RGDID:	3554	Length:	402	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	163/411 - (39%)
Similarity:	236/411 - (57%)	Gaps:	24/411 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLLVSLLPVLFILPVQFQHPVSCKLQL-------YRVPLRRFPSARHRFEKLGIRMDRLRLKYA 58
            :|.|:.|.             .||...|       .|:.|::.||.|...|:.|:.|.|:..::.
  Rat     8 LWALLLLW-------------TSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWG 59

  Fly    59 EEVSHFRGEWNSAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVAC 123
            |.:.  :..:.:......|:||||.||:|.|.||||.|||||||||||:||||||..|.....||
  Rat    60 EFIK--KSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTAC 122

  Fly   124 RVHNRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAA 188
            .:||.|.:..|:|:...|..|.||||||.:.||||.|.|.|.|: |..|||.|.||:|...|:.|
  Rat   123 EIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGI-IVTQTFGEVTELPLIPFMLA 186

  Fly   189 KFDGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEKDGGAIFFGGSNPHYYTGNF 253
            ||||:.|:.:.:.::..:.|.|..::.|.:|.:.:||||.||.....||.:..|||:|.:|.|||
  Rat   187 KFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNF 251

  Fly   254 TYVQVSHRAYWQVKMDSAVIRNLE-LCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQ 317
            .||.:|....||:.|....:.... ||::||..::|||||:::.|.....||.:::|........
  Rat   252 HYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANN 316

  Fly   318 FLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVF 382
            ::|.|..||.||.|:|.||||.:.|.:.:||.::.:::..:|..|...:|:|.|:||:|:||..|
  Rat   317 YVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATF 381

  Fly   383 LGKYYTEFDMERHRIGFADAR 403
            :.|:|||||...:|||||.||
  Rat   382 IRKFYTEFDRHNNRIGFALAR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	10/32 (31%)
		pepsin_retropepsin_like	76..400	CDD:299705	143/324 (44%)
		Asp	84..402	CDD:278455	140/318 (44%)
Ren	NP_036774.4	A1_Propeptide	31..64	CDD:400357	10/34 (29%)
Ren	NP_036774.4	renin_like	76..401	CDD:133154	145/325 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20151
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120302
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790