Protein Alignment CG10104 and BACE1

DIOPT Version :9

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_036236.1
• Gene: BACE1 / 23621
• HGNCID: 933
• Length: 501
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 114/455 - (25%)
• Similarity: 185/455 - (40%)
• Gaps: 103/455 - (22%)

  Fly     1 MWLLVSLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDR----------LRL 55
            :|:...:||.     ...||.:       |:|||.....    ..||:|:.|          .|.
Human    10 LWMGAGVLPA-----HGTQHGI-------RLPLRSGLGG----APLGLRLPRETDEEPEEPGRRG 58

  Fly    56 KYAEEVSHFRGEWNSAVKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTM 120
            .:.|.|.:.||:....             |:..:|:|:||||..::.||||||..|.:|.
Human    59 SFVEMVDNLRGKSGQG-------------YYVEMTVGSPPQTLNILVDTGSSNFAVGAAP----- 105

  Fly   121 VACRVH---NRYFAKR--STSHQVRGDHFAIHYGSGSLSGFLSTDTVRV---AGLEIRDQTFAEA 177
                 |   :||:.::  ||...:|...: :.|..|...|.|.||.|.:   ..:.:| ...|..
Human   106 -----HPFLHRYYQRQLSSTYRDLRKGVY-VPYTQGKWEGELGTDLVSIPHGPNVTVR-ANIAAI 163

  Fly   178 TEMPGPIFLAAKFDGIFGLAYRSISM--QRIKPPFYAMMEQGLLTKPIFSVYLSRNG-------- 232
            ||........:.::||.||||..|:.  ..::|.|.::::|..:.. :||:.|...|
Human   164 TESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEV 227

  Fly   233 -EKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVIRNLELCQQGC------EVIIDTG 290
             ...||::..||.:...|||:..|..:....|::|.:....|...:| :..|      :.|:|:|
Human   228 LASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL-KMDCKEYNYDKSIVDSG 291

  Fly   291 TSFLALP---YDQAILINESIGGT---PSSF--GQFLV--PCDSVP--DLPKITFTLGGR----- 338
            |:.|.||   ::.|:...::...|   |..|  |:.||  ...:.|  ..|.|:..|.|.
Human   292 TTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQS 356

  Fly   339 -RFFLESHEYV--FRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
             |..:...:|:  ..|:...:..|....|     |.|....::|.|.:..:|..||..|.|||||
Human   357 FRITILPQQYLRPVEDVATSQDDCYKFAI-----SQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

  Fly   401  400
            Human   417  416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	8/35 (23%)
		pepsin_retropepsin_like	76..400	CDD:299705	94/368 (26%)
		Asp	84..402	CDD:278455	96/362 (27%)
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..58		4/18 (22%)
		beta_secretase_like	72..437	CDD:133140	96/377 (25%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269|PubMed:15886016	496..500

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810