DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and asp-14

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_509082.2	Gene:	asp-14 / 180917	WormBaseID:	WBGene00019619	Length:	366	Species:	Caenorhabditis elegans

Alignment Length:	333	Identity:	84/333 - (25%)
Similarity:	144/333 - (43%)	Gaps:	37/333 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHYGSGSL 153
            :|:|||.|.|.|:.||.::::.:|..:| .|...|....|:...:|:|:...|:.:......|:.
Worm    48 LTMGTPGQLFTVVIDTSTADIVIPDMSC-KTANNCYNKRRFNQAKSSSYYAYGNKYTYKNNLGTF 111

  Fly   154 SGFLSTDTVRVAG-----LEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAM 213
            .||.:.|||.:..     :.|....|.:||:: |.:......|||.||.:.:.|......||...
Worm   112 QGFDAKDTVVIGDRKTDLITIPGVKFMQATDL-GLLMDGLGADGILGLGFTASSQIGGNSPFVQG 175

  Fly   214 MEQGLLTKPIFSVYLSRNGEKDG----GAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVIR 274
            :..|.::...:|::|....:.|.    |.|::||.:|.:...|.|||.::....:|:.|.|..:.
Worm   176 VNAGDISGTFYSIWLEHFNQTDDLGTHGVIYYGGFDPVHCAPNPTYVPLASAYAYQLTMSSFKVV 240

  Fly   275 NLELCQQGCEVI---IDTGTSFLALPYDQAILINESIG---GTPSSFGQFLVPCDSVPDLPKITF 333
            .........:.|   :||.|:.:.||......:.:|:|   ...::....:|||::     |||.
Worm   241 GSSATNSNNKYIQTYLDTTTAQIGLPKTYISQVFDSLGISTNVMNAIYPTIVPCNT-----KITL 300

  Fly   334 TLG---GRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILG-DVFLGKYYTEFDMER 394
            |.|   |....:...:.|....    ..|....|      |:....||| .::.|: .|.||...
Worm   301 TFGFVSGTTVSITERDLVISFF----GTCRLQII------PTTDRIILGLPLYRGR-CTYFDPIM 354

  Fly   395 HRIGFADA 402
            .|:||..|
Worm   355 QRVGFTPA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240
		pepsin_retropepsin_like	76..400	CDD:299705	82/329 (25%)
		Asp	84..402	CDD:278455	83/331 (25%)
asp-14	NP_509082.2	pepsin_like	44..361	CDD:133138	83/330 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820