DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and asp-1

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_741677.1	Gene:	asp-1 / 180251	WormBaseID:	WBGene00000214	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	395	Identity:	122/395 - (30%)
Similarity:	195/395 - (49%)	Gaps:	30/395 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGEWNSAVKSTPLSNYLDAQYFG 87
            :|...:.:||..:..|.|.:..|.|.....|..::|....    :.|:..:  |..:|.|..|.|
Worm    12 ACSAAVIQVPTHKTESLRAKLIKEGKYTAFLASQHAARAQ----QLNTGFQ--PFVDYFDDFYLG 70

  Fly    88 PITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACR-------VHNRYFAKRSTSHQVRGDHFA 145
            .||:|||||...|:.|||||||||..|.|.:.  ||.       ...::...:||:.......|:
Worm    71 NITLGTPPQPATVVLDTGSSNLWVIDAACKTQ--ACNGYPDSGYTKQKFDTTKSTTFVKETRKFS 133

  Fly   146 IHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPF 210
            |.|||||.:|:|..|.:...||.::.|.|..:|.: ..:|.....|||.||.:.::::.::.||.
Worm   134 IQYGSGSCNGYLGKDVLNFGGLTVQSQEFGVSTHL-ADVFGYQPVDGILGLGWPALAVDQVVPPM 197

  Fly   211 YAMMEQGLLTKPIFSVYLSRNGE----KDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSA 271
            ..::.|..|..|:|:|:|.||.:    ..||.|.:|..:........|||.:|.:.|||..:|:.
Worm   198 QNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAF 262

  Fly   272 VIRNLELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFG----QFLVPCDSVPDLPKIT 332
            .:......::. :||.|||||:|..|   ..:::..:..|.:.|.    .:.|.|.::...|.:.
Worm   263 AVGTYSETKKD-QVISDTGTSWLGAP---NTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQPDLI 323

  Fly   333 FTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRI 397
            ||:||.:|.::|.|||. |:......|:.|..::. ....||.|||||.|:.:|...:|:...:|
Worm   324 FTIGGAQFPVKSVEYVL-DLQLGGGKCALAVFSMG-SGGFGPSWILGDTFIRQYCNVYDIGNGQI 386

  Fly   398 GFADA 402
            |||.|
Worm   387 GFATA 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	6/25 (24%)
		pepsin_retropepsin_like	76..400	CDD:299705	109/338 (32%)
		Asp	84..402	CDD:278455	108/332 (33%)
asp-1	NP_741677.1	A1_Propeptide	17..45	CDD:369623	7/27 (26%)
asp-1	NP_741677.1	Asp	67..391	CDD:365818	108/332 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860