DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and asp-6

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_505133.1	Gene:	asp-6 / 179209	WormBaseID:	WBGene00000219	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	109/360 - (30%)
Similarity:	174/360 - (48%)	Gaps:	32/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 YAEEVSHFRGEWNSAVKSTP--LSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCAST 119
            |.|...:.|....:.:.:.|  ::::.|.:|.|.||||||.|.|.|:.||||||||:|..||.:.
Worm    41 YLEYQRNLRAVSPNVLANLPQNVNDFGDFEYLGNITIGTPDQGFIVVLDTGSSNLWIPGPTCKTN 105

  Fly   120 MVACRVHNRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRVAG-----LEIRDQTFAEATE 179
               |:..:::.:..|::....|..:.|.||||..:|.|..||||...     |.:...||..|::
Worm   106 ---CKTKSKFDSTASSTFVKNGKSWTIQYGSGDAAGILGQDTVRFGAKGDSQLSVPTTTFGIASK 167

  Fly   180 MPGPIFLAAKF-----DGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEKD--GG 237
                  ::|.|     |||.|||:.|:::..:.||....:.||:|.:|:|||:|...|..:  ||
Worm   168 ------ISADFKNDATDGILGLAFTSLAVDGVVPPLINAINQGILDQPLFSVWLEHRGAANNVGG 226

  Fly   238 AIF-FGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVIRNLELCQQGCEVIIDTGTSFLALPYDQA 301
            .:| :|..:.........|..:|...|:|.|.....:.:....:. .:||.|||||||..|....
Worm   227 GVFTYGAIDTTNCGALVAYQPLSSATYYQFKAAGFKLGSYSNTKT-VDVISDTGTSFLGGPQSVV 290

  Fly   302 ILINESIGGTPSSFGQ-FLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIA 365
            ..:.::.|.|...|.: :.:.|.:.|.  .:..|:|...:.::...|:   :......|..|...
Worm   291 DGLAKAAGATYDDFNEVYFIDCAAQPG--TLDITIGTNTYSIQPVNYI---VDAGNGQCLFAAFP 350

  Fly   366 VDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
            .|. ...||.|||||.|:.:|...:|:...|:|||
Worm   351 FDF-GGFGPSWILGDPFIRQYCNIYDIGNKRMGFA 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240
		pepsin_retropepsin_like	76..400	CDD:299705	104/339 (31%)
		Asp	84..402	CDD:278455	104/331 (31%)
asp-6	NP_505133.1	Asp	70..385	CDD:278455	104/331 (31%)
asp-6	NP_505133.1	pepsin_like	71..385	CDD:133138	104/330 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920