DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and Ctsd

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_599161.2	Gene:	Ctsd / 171293	RGDID:	621511	Length:	407	Species:	Rattus norvegicus

Alignment Length:	392	Identity:	179/392 - (45%)
Similarity:	249/392 - (63%)	Gaps:	25/392 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGEWNSAVKSTP---------LSNYLDA 83
            |.|:|||:|.|.|....::|..::.|.||  ..::.:      :::|:|         |.|||||
  Rat    21 LIRIPLRKFTSIRRTMTEVGGSVEDLILK--GPITKY------SMQSSPRTKEPVSELLKNYLDA 77

  Fly    84 QYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHY 148
            ||:|.|.||||||.|.|:||||||||||||..|....:||.||::|.:.:|:::...|..|.|||
  Rat    78 QYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHY 142

  Fly   149 GSGSLSGFLSTDTVRV------AGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIK 207
            |||||||:||.|||.|      .|:::..|.|.|||:.||.:|:|||||||.|:.|..||:..:.
  Rat   143 GSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNNVL 207

  Fly   208 PPFYAMMEQGLLTKPIFSVYLSRNGE-KDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSA 271
            |.|..:|:|.|:.|.|||.||:|:.. :.||.:..||::..||.|..:|:.|:.:|||||.||..
  Rat   208 PVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQL 272

  Fly   272 VI-RNLELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCDSVPDLPKITFTL 335
            .: ..|.||:.|||.|:|||||.|..|.|:...:.::||..|...|::::||:.|..||.|||.|
  Rat   273 EVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKL 337

  Fly   336 GGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
            ||:.:.|...:|:.:.....:.||.|.|:.:|:|.||||||||||||:|.|||.||.|.:|:|||
  Rat   338 GGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFA 402

  Fly   401 DA 402
            .|
  Rat   403 KA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	9/25 (36%)
		pepsin_retropepsin_like	76..400	CDD:299705	163/340 (48%)
		Asp	84..402	CDD:278455	158/325 (49%)
Ctsd	NP_599161.2	A1_Propeptide	21..46	CDD:285240	9/24 (38%)
		Cathepsin_D2	73..403	CDD:133157	162/329 (49%)
		Asp	78..404	CDD:278455	158/325 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm44891
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930