Protein Alignment CG10104 and CTSE

DIOPT Version :9

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 164/424 - (38%)
• Similarity: 239/424 - (56%)
• Gaps: 52/424 - (12%)

  Fly     3 LLVSLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGE 67
            ||:.||.:|.:...|.        .|:||||||.||.:.            :|:...::|.|
Human     4 LLLLLLVLLELGEAQG--------SLHRVPLRRHPSLKK------------KLRARSQLSEF--- 45

  Fly    68 WNS----AVKST-----------PLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCA 117
            |.|    .::.|           ||.||||.:|||.|:||:|||.|.||||||||||||||..|.
Human    46 WKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT 110

  Fly   118 STMVACRVHNRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTV-----RVAGLEIRDQTFAEA 177
            |.  ||:.|:|:...:|:::...|..|:|.||:|||||.:..|.|     :|.||.:..|.|.|:
Human   111 SP--ACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGES 173

  Fly   178 TEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEKDGGA---I 239
            ...||..|:.|:||||.||.|.|:::..:.|.|..||.|.|:..|:||||:|.|.|  |||   :
Human   174 VTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPE--GGAGSEL 236

  Fly   240 FFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVI-RNLELCQQGCEVIIDTGTSFLALPYDQAIL 303
            .|||.:..:::|:..:|.|:.:||||:.:|:..: ..:..|.:||:.|:|||||.:..|.|:...
Human   237 IFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 301

  Fly   304 INESIGGTPSSFGQFLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDL 368
            :..:||..|.. |::.|.|.::..:|.:|||:.|..:.|....|...|.....:.|||.|..:|:
Human   302 LQNAIGAAPVD-GEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI 365

  Fly   369 PSPSGPLWILGDVFLGKYYTEFDMERHRIGFADA 402
            ..|:||||||||||:.::|:.||...:|:|.|.|
Human   366 HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPA 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	9/25 (36%)
		pepsin_retropepsin_like	76..400	CDD:299705	141/332 (42%)
		Asp	84..402	CDD:278455	136/326 (42%)
CTSE	XP_011507546.1	A1_Propeptide	21..49	CDD:285240	13/42 (31%)
		Asp	77..399	CDD:278455	136/326 (42%)
		Cathespin_E	78..398	CDD:133153	135/324 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860