DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and CTSD

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001900.1	Gene:	CTSD / 1509	HGNCID:	2529	Length:	412	Species:	Homo sapiens

Alignment Length:	419	Identity:	182/419 - (43%)
Similarity:	256/419 - (61%)	Gaps:	36/419 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SLLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRL-----KYAEEVSHFR 65
            ||||:...|   ...|.|.   |.|:||.:|.|.|....::|..::.|..     ||::.|
Human     5 SLLPLALCL---LAAPASA---LVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAV---- 59

  Fly    66 GEWNSAVKSTP----LSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVH 126
                .||...|    |.||:||||:|.|.||||||.|.|:||||||||||||..|....:||.:|
Human    60 ----PAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120

  Fly   127 NRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRV-----------AGLEIRDQTFAEATEM 180
            ::|.:.:|:::...|..|.||||||||||:||.|||.|           .|:::..|.|.|||:.
Human   121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQ 185

  Fly   181 PGPIFLAAKFDGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGE-KDGGAIFFGGS 244
            ||..|:|||||||.|:||..||:..:.|.|..:|:|.|:.:.|||.||||:.: :.||.:..||:
Human   186 PGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGT 250

  Fly   245 NPHYYTGNFTYVQVSHRAYWQVKMDSA-VIRNLELCQQGCEVIIDTGTSFLALPYDQAILINESI 308
            :..||.|:.:|:.|:.:|||||.:|.. |...|.||::|||.|:|||||.:..|.|:...:.::|
Human   251 DSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAI 315

  Fly   309 GGTPSSFGQFLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSG 373
            |..|...|::::||:.|..||.||..|||:.:.|...:|..:.....:.:|.|.|:.:|:|.|||
Human   316 GAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSG 380

  Fly   374 PLWILGDVFLGKYYTEFDMERHRIGFADA 402
            |||||||||:|:|||.||.:.:|:|||:|
Human   381 PLWILGDVFIGRYYTVFDRDNNRVGFAEA 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	8/25 (32%)
		pepsin_retropepsin_like	76..400	CDD:299705	158/340 (46%)
		Asp	84..402	CDD:278455	154/330 (47%)
CTSD	NP_001900.1	A1_Propeptide	22..49	CDD:400357	8/26 (31%)
CTSD	NP_001900.1	Cathepsin_D2	73..408	CDD:133157	157/334 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	390	1.000	Domainoid score	I789
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1750
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm40751
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.940