DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and Ctsd

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_034113.1	Gene:	Ctsd / 13033	MGIID:	88562	Length:	410	Species:	Mus musculus

Alignment Length:	417	Identity:	182/417 - (43%)
Similarity:	256/417 - (61%)	Gaps:	37/417 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRL-----KYAEEVSHFRG 66
            ||.:|.:|       .|....:.|:|||:|.|.|....::|..::.|.|     ||:.:
Mouse     7 LLLILGLL-------ASSSFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQ------ 58

  Fly    67 EWNSAVKSTP-----LSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVH 126
               |:.|:|.     |.|||||||:|.|.||||||.|.|:||||||||||||..|....:||.||
Mouse    59 ---SSPKTTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVH 120

  Fly   127 NRYFAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRV---------AGLEIRDQTFAEATEMPG 182
            ::|.:.:|:::...|..|.||||||||||:||.|||.|         .|:::..|.|.|||:.||
Mouse   121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPG 185

  Fly   183 PIFLAAKFDGIFGLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGE-KDGGAIFFGGSNP 246
            .:|:|||||||.|:.|..||:..:.|.|..:|:|.|:.|.|||.||:|:.| :.||.:..||::.
Mouse   186 IVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDS 250

  Fly   247 HYYTGNFTYVQVSHRAYWQVKMDSAVIRN-LELCQQGCEVIIDTGTSFLALPYDQAILINESIGG 310
            .||.|..:|:.|:.:|||||.||...:.| |.||:.|||.|:|||||.|..|.::...:.::||.
Mouse   251 KYYHGELSYLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGA 315

  Fly   311 TPSSFGQFLVPCDSVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPL 375
            .|...|::::||:.|..||.:...|||:.:.|...:|:.:.....:.||.|.|:.:|:|.|||||
Mouse   316 VPLIQGEYMIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPL 380

  Fly   376 WILGDVFLGKYYTEFDMERHRIGFADA 402
            |||||||:|.|||.||.:.:|:|||:|
Mouse   381 WILGDVFIGSYYTVFDRDNNRVGFANA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	8/25 (32%)
		pepsin_retropepsin_like	76..400	CDD:299705	159/339 (47%)
		Asp	84..402	CDD:278455	155/328 (47%)
Ctsd	NP_034113.1	A1_Propeptide	21..46	CDD:285240	8/24 (33%)
		Cathepsin_D2	73..405	CDD:133157	158/331 (48%)
		Asp	78..407	CDD:278455	155/328 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1696
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm42823
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.940