DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and nots

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_571879.1	Gene:	nots / 114367	ZFINID:	ZDB-GENE-010620-1	Length:	416	Species:	Danio rerio

Alignment Length:	388	Identity:	141/388 - (36%)
Similarity:	227/388 - (58%)	Gaps:	19/388 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LYRVPLRRFPSARHRFEKLG--------IRMDRLRLKYAE---EVSHFRGEWNSAVKSTPLSNYL 81
            |.||.||::||.|.|.....        .:.|....:|.:   ...||........:.  |.|::
Zfish    20 LLRVALRQYPSVRSRLRASAQLEEFLKQHQPDMFSRRYVQCFPPAQHFLRPGRRVTER--LYNFM 82

  Fly    82 DAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAI 146
            |||:||.|::|.|.|.|.|:||||||:|||||:.|.:.  ||.:||::.|..|:::...|..|.|
Zfish    83 DAQFFGQISLGRPEQNFTVVFDTGSSDLWVPSSYCVTQ--ACALHNKFKAFESSTYTHDGRVFGI 145

  Fly   147 HYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSISMQRIKPPFY 211
            |||||.|.|.::.|.::|..:.:::|.|.||...||..|:.|:|||:.||.:..::.::..|.|.
Zfish   146 HYGSGHLLGVMARDELKVGSVRVQNQVFGEAVYEPGFSFVLAQFDGVLGLGFPQLAEEKGSPVFD 210

  Fly   212 AMMEQGLLTKPIFSVYLSRNGEKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQVKMDSAVIRNL 276
            .||||.:|.:|:||.||:.||...||.:.||.::...:.....::.|:.:.|||:|:|:..::..
Zfish   211 TMMEQNMLDQPVFSFYLTNNGSGFGGELVFGANDESRFLPPINWIPVTQKGYWQIKLDAVKVQGA 275

  Fly   277 ----ELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCDSVPDLPKITFTLGG 337
                :...|||:.|:|||||.:..|....:::.:.||.||::.|:|:|.|..|..||.::|.:..
Zfish   276 LSFSDRSVQGCQAIVDTGTSLIGGPARDILILQQFIGATPTANGEFVVDCVRVSSLPVVSFLINS 340

  Fly   338 RRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
            ..:.|...:||.|:...:::||.|.|.::::|||:||:||||||||.:.|:.:|...:|:|.|
Zfish   341 VEYSLSGEQYVRRETLNNKQICFSGFQSIEVPSPAGPVWILGDVFLSQVYSIYDRGENRVGLA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	10/33 (30%)
		pepsin_retropepsin_like	76..400	CDD:299705	127/327 (39%)
		Asp	84..402	CDD:278455	124/321 (39%)
nots	NP_571879.1	A1_Propeptide	20..48	CDD:285240	9/27 (33%)
		Asp	85..403	CDD:278455	123/319 (39%)
		pepsin_retropepsin_like	86..403	CDD:299705	122/318 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030