DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10104 and bace2

DIOPT Version :9

Sequence 1:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001135590.1	Gene:	bace2 / 100216145	XenbaseID:	XB-GENE-1014090	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	373	Identity:	95/373 - (25%)
Similarity:	143/373 - (38%)	Gaps:	92/373 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 YFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHYG 149
            |:..:.||||||...::.||||||..|..|....      :...:.:|.|||::.......:.|.
Frog    75 YYLELLIGTPPQKMNILVDTGSSNFAVAGALNPD------ITTFFDSKLSTSYEPLNTQVTVRYT 133

  Fly   150 SGSLSGFLSTDTVRVAGLEIRDQTFAEATEMP-----------GPIFLAAKF-------DGIFGL 196
            .||.:|.|..|.:                .||           ..||.:..|       .||.||
Frog   134 QGSWTGLLGKDVI----------------SMPKGVNGTFLINIASIFQSENFFLPNINWQGILGL 182

  Fly   197 AYRSISMQRIKP-----PFYAMMEQGLLTKPIFSVYLSRNGEK------DGGAIFFGGSNPHYYT 250
            ||.:::    ||     ||:..:.|......|||:.:...|:.      :.|::..||..|..|.
Frog   183 AYSTLA----KPSSSVEPFFDSLVQQENIPNIFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQ 243

  Fly   251 GNFTYVQVSHRAYWQVKMDSAVI--RNLELCQQGCEV------IIDTGTSFLALPYDQ------- 300
            |:..|..::...|:||::....:  :||.|   .|.|      |:|:||:.|.|| |:
Frog   244 GDIWYTPITEEWYYQVEVLKFEVGGQNLNL---DCTVYNSDKAIVDSGTTLLRLP-DKVFNAMVD 304

  Fly   301 AILINESIGGTPSSF--GQFLVPCDSVPD----LPKITF----TLGGRRFFLESHEYVFRD---I 352
            ||:....|....:.|  |..|...|...|    .|.|:.    |...|.|.|.....::..   .
Frog   305 AIVQTSLIQNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLT 369

  Fly   353 YQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
            :|:...|....|     |.|....::|...:..:|..||....|:|||
Frog   370 FQESLNCFRFGI-----SQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240
		pepsin_retropepsin_like	76..400	CDD:299705	93/371 (25%)
		Asp	84..402	CDD:278455	95/373 (25%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	95/373 (25%)
bace2	NP_001135590.1	Asp	75..412	CDD:278455	93/371 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910