Protein Alignment CG10104 and bace2

DIOPT Version :10

• Sequence 1: NP_610961.1
• Gene: CG10104 / 36602
• FlyBaseID: FBgn0033933
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 373
• Identity: 95/373 - (25%)
• Similarity: 143/373 - (38%)
• Gaps: 92/373 - (24%)

  Fly    85 YFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTSHQVRGDHFAIHYG 149
            |:..:.||||||...::.||||||..|..|....      :...:.:|.|||::.......:.|.
 Frog    75 YYLELLIGTPPQKMNILVDTGSSNFAVAGALNPD------ITTFFDSKLSTSYEPLNTQVTVRYT 133

  Fly   150 SGSLSGFLSTDTVRVAGLEIRDQTFAEATEMP-----------GPIFLAAKF-------DGIFGL 196
            .||.:|.|..|.:                .||           ..||.:..|       .||.||
 Frog   134 QGSWTGLLGKDVI----------------SMPKGVNGTFLINIASIFQSENFFLPNINWQGILGL 182

  Fly   197 AYRSISMQRIKP-----PFYAMMEQGLLTKPIFSVYLSRNGEK------DGGAIFFGGSNPHYYT 250
            ||.:::    ||     ||:..:.|......|||:.:...|:.      :.|::..||..|..|.
 Frog   183 AYSTLA----KPSSSVEPFFDSLVQQENIPNIFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQ 243

  Fly   251 GNFTYVQVSHRAYWQVKMDSAVI--RNLELCQQGCEV------IIDTGTSFLALPYDQ------- 300
            |:..|..::...|:||::....:  :||.|   .|.|      |:|:||:.|.|| |:
 Frog   244 GDIWYTPITEEWYYQVEVLKFEVGGQNLNL---DCTVYNSDKAIVDSGTTLLRLP-DKVFNAMVD 304

  Fly   301 AILINESIGGTPSSF--GQFLVPCDSVPD----LPKITF----TLGGRRFFLESHEYVFRD---I 352
            ||:....|....:.|  |..|...|...|    .|.|:.    |...|.|.|.....::..   .
 Frog   305 AIVQTSLIQNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLT 369

  Fly   353 YQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMERHRIGFA 400
            :|:...|....|     |.|....::|...:..:|..||....|:|||
 Frog   370 FQESLNCFRFGI-----SQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10104	NP_610961.1	pepsin_retropepsin_like	76..400	CDD:472175	93/371 (25%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	95/373 (25%)