Protein Alignment Dh44-R1 and GLP2R

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_011522379.1
• Gene: GLP2R / 9340
• HGNCID: 4325
• Length: 578
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 123/444 - (27%)
• Similarity: 202/444 - (45%)
• Gaps: 87/444 - (19%)

  Fly    53 CLTQFDSILCWPRTARGTLAVLQC----------MDELQG---------------IHYDSSKNAT 92
            |...||..:|||.::.|.::| .|          ..::||               ...:||..|.
Human    96 CNGTFDQYVCWPHSSPGNVSV-PCPSYLPWWSEDHQQIQGQLKLFSGKISGYKLQAKQESSGRAY 159

  Fly    93 RFCHANGTWEKYTNY-------DACAHLPA-PESVPEFEVIVELPTIIYYIGYTLSLVSLSLALI 149
            |.|.|.|||:...|.       ..|:...: .::|..:.::..| .::|.:||:.||:||.|||.
Human   160 RHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTL-QLMYTVGYSFSLISLFLALT 223

  Fly   150 VFAYFKELRCLRNTIHANLFFTYIMSALF---------------------WILLLSVQISIRSGV 193
            :..:.::|.|.||.||.|||.::|:..|.                     |:..||...:
Human   224 LLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMST----- 283

  Fly   194 GSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAK 258
             ||.::..|.|:|...|:.|:|||||||:.|:..|...:...:..|..:||..|.||||.|..|:
Human   284 -SCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFAR 347

  Fly   259 S---LTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVET 320
            :   .|..::|....:|   |       ||.:||:...:.:|....|:|:.:||:||: |:.:..
Human   348 AHLENTGCWTTNGNKKI---W-------WIIRGPMMLCVTVNFFIFLKILKLLISKLK-AHQMCF 401

  Fly   321 RQYR-KAAKALLVLIPLFGITYLV--VLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNS 382
            |.|: :.||:.||||||.|:..::  .:......|....:...::..|.|..||.|:|.|.|.|.
Human   402 RDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANG 466

  Fly   383 EVRNALRHH-----ISTWRDTRTIQLNQNRRY---TTKSFSKGGGSPRAESMRP 428
            ||:..||.:     ::.....|...|.::.|:   ..|..|:|.|:.:...::|
Human   467 EVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQP 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	22/90 (24%)
		7tmB1_DH_R	126..394	CDD:320391	92/299 (31%)
		TM helix 1	128..153	CDD:320391	11/24 (46%)
		TM helix 2	162..184	CDD:320391	9/42 (21%)
		TM helix 3	197..224	CDD:320391	12/26 (46%)
		TM helix 4	236..256	CDD:320391	9/19 (47%)
		TM helix 5	279..308	CDD:320391	7/28 (25%)
		TM helix 6	322..349	CDD:320391	10/29 (34%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
GLP2R	XP_011522379.1	HRM	93..187	CDD:397086	22/91 (24%)
		7tmB1_GLP2R	200..478	CDD:320394	92/295 (31%)
		TM helix 1	202..227	CDD:320394	11/25 (44%)
		TM helix 2	236..258	CDD:320394	8/21 (38%)
		TM helix 3	286..313	CDD:320394	12/26 (46%)
		TM helix 4	325..345	CDD:320394	9/19 (47%)
		TM helix 5	361..390	CDD:320394	9/38 (24%)
		TM helix 6	404..431	CDD:320394	10/26 (38%)
		TM helix 7	440..465	CDD:320394	8/24 (33%)