DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and GLP2R

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011522379.1	Gene:	GLP2R / 9340	HGNCID:	4325	Length:	578	Species:	Homo sapiens

Alignment Length:	444	Identity:	123/444 - (27%)
Similarity:	202/444 - (45%)	Gaps:	87/444 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CLTQFDSILCWPRTARGTLAVLQC----------MDELQG---------------IHYDSSKNAT 92
            |...||..:|||.::.|.::| .|          ..::||               ...:||..|.
Human    96 CNGTFDQYVCWPHSSPGNVSV-PCPSYLPWWSEDHQQIQGQLKLFSGKISGYKLQAKQESSGRAY 159

  Fly    93 RFCHANGTWEKYTNY-------DACAHLPA-PESVPEFEVIVELPTIIYYIGYTLSLVSLSLALI 149
            |.|.|.|||:...|.       ..|:...: .::|..:.::..| .::|.:||:.||:||.|||.
Human   160 RHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTL-QLMYTVGYSFSLISLFLALT 223

  Fly   150 VFAYFKELRCLRNTIHANLFFTYIMSALF---------------------WILLLSVQISIRSGV 193
            :..:.::|.|.||.||.|||.::|:..|.                     |:..||...:
Human   224 LLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMST----- 283

  Fly   194 GSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAK 258
             ||.::..|.|:|...|:.|:|||||||:.|:..|...:...:..|..:||..|.||||.|..|:
Human   284 -SCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFAR 347

  Fly   259 S---LTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVET 320
            :   .|..::|....:|   |       ||.:||:...:.:|....|:|:.:||:||: |:.:..
Human   348 AHLENTGCWTTNGNKKI---W-------WIIRGPMMLCVTVNFFIFLKILKLLISKLK-AHQMCF 401

  Fly   321 RQYR-KAAKALLVLIPLFGITYLV--VLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNS 382
            |.|: :.||:.||||||.|:..::  .:......|....:...::..|.|..||.|:|.|.|.|.
Human   402 RDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANG 466

  Fly   383 EVRNALRHH-----ISTWRDTRTIQLNQNRRY---TTKSFSKGGGSPRAESMRP 428
            ||:..||.:     ::.....|...|.::.|:   ..|..|:|.|:.:...::|
Human   467 EVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	22/90 (24%)
		7tmB1_DH_R	126..394	CDD:320391	92/299 (31%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	9/41 (22%)
		TM helix 3	197..219	CDD:320391	8/21 (38%)
		TM helix 4	238..254	CDD:320391	8/15 (53%)
		TM helix 5	279..302	CDD:320391	5/22 (23%)
		TM helix 6	327..349	CDD:320391	9/23 (39%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
GLP2R	XP_011522379.1	HRM	93..187	CDD:280888	22/91 (24%)
GLP2R	XP_011522379.1	7tm_2	200..457	CDD:278432	83/274 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810