DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and Sctr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_038947043.1	Gene:	Sctr / 81779	RGDID:	621342	Length:	464	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	122/394 - (30%)
Similarity:	190/394 - (48%)	Gaps:	44/394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SGHCLTQ-----FDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRF--CHANGTWEKYTNY 107
            |.|.:.|     :|::.|||.:|......:||...|..:   |:||.:.|  |..:|..|.:...
  Rat    73 SSHAVYQGCEGLWDNMSCWPSSAPARTVEVQCPKFLLML---SNKNGSLFRNCTQDGWSETFPRP 134

  Fly   108 DACAHLPAPESVPE--FEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFF 170
            |....:....|..|  ...:::| .::|.:||:.||..|.:||.:...|:.|.|.||.||.:||.
  Rat   135 DLACGVNINNSFNERRHAYLLKL-KVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFV 198

  Fly   171 TYIMSALF-----WILLLSVQISIRSG--VGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKT 228
            ::|:.||.     .:|..|..::....  || |..::..|.:..:.|:.|:|||||||:.|:..:
  Rat   199 SFILRALSNFIKDAVLFSSDDVTYCDAHKVG-CKLVMIFFQYCIMANYAWLLVEGLYLHTLLAIS 262

  Fly   229 FSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAV 293
            |..:......:..:|||.||:||..||:.:........   ::||.    ...|.|:.:|||...
  Rat   263 FFSERKYLQAFVLLGWGSPAIFVALWAITRHFLENTGC---WDINA----NASVWWVIRGPVILS 320

  Fly   294 LIINLTFLLRIMWVLITKLRSANT--VETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGH 356
            ::||..|.:.|:.:|:.|||:..|  .||..|::.||:.|:|||||||.|:|....| |..:...
  Rat   321 ILINFIFFINILRILMRKLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSP-EDAMEVQ 384

  Fly   357 MFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWR----DTRTIQLNQNRRYTTKSFSKG 417
            :|..|  .|.|.||..|::.|||||.||:..::.....|.    ..|.:..|       .|||..
  Rat   385 LFFEL--ALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFN-------NSFSNA 440

  Fly   418 GGSP 421
            ...|
  Rat   441 TNGP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	18/66 (27%)
		7tmB1_DH_R	126..394	CDD:320391	94/276 (34%)
		TM helix 1	129..153	CDD:320391	8/23 (35%)
		TM helix 2	162..183	CDD:320391	9/25 (36%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	8/22 (36%)
		TM helix 6	327..349	CDD:320391	12/21 (57%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
Sctr	XP_038947043.1	HormR	80..147	CDD:214468	17/69 (25%)
		7tmB1_secretin	154..420	CDD:320403	94/277 (34%)
		TM helix 1	157..181	CDD:320403	9/24 (38%)
		TM helix 2	190..211	CDD:320403	8/20 (40%)
		TM helix 3	231..253	CDD:320403	6/21 (29%)
		TM helix 4	272..288	CDD:320403	7/15 (47%)
		TM helix 5	306..329	CDD:320403	8/22 (36%)
		TM helix 6	356..378	CDD:320403	13/22 (59%)
		TM helix 7	382..407	CDD:320403	10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810