Protein Alignment Dh44-R1 and Pth2r

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_112351.2
• Gene: Pth2r / 81753
• RGDID: 620612
• Length: 546
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 139/466 - (29%)
• Similarity: 219/466 - (46%)
• Gaps: 64/466 - (13%)

  Fly    32 ELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKN--ATRF 94
            ::||  :.:|.|. :....|:|..::|.::||||...|..:.:.|...:    ||.:..  |.|.
  Rat    45 KMQC--ELNITAQ-FQEGEGNCFPEWDGLICWPRGTAGKTSAMPCPSYV----YDFNHKGVAFRH 102

  Fly    95 CHANGTWE-------KYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFA 152
            |..||||:       .:.||..| .|....::.:.|....| .|:|.:||::|..||::|:::..
  Rat   103 CTPNGTWDFIHGSNKTWANYSDC-FLQPDINIGKQEFFENL-YILYTVGYSISFGSLAVAILIIG 165

  Fly   153 YFKELRCLRNTIHANLFFTYIMSALFWIL---------------LLSVQISIRSGVG-------- 194
            ||:.|.|.||.||.:||.::::.|:...:               .|.:|..:::.:|
  Rat   166 YFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQ 230

  Fly   195 --SCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVA 257
              .|...:.:|.:|..||::|:|||||||:.|:..:|..|......:..||||.||:|||.||||
  Rat   231 YVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFILIGWGFPAVFVVAWAVA 295

  Fly   258 KSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTV---E 319
            ::...        :..| |.......||||.|:.|.:.:|....|..:.||.||:...|.|   .
  Rat   296 RATLA--------DTRC-WELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDM 351

  Fly   320 TRQYRKAAKALLVLIPLFGITYLVVLAGP-SESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSE 383
            .:||||.||:.|||:.:||:.|:|.:..| |.|||...:.........|.|||.||:.||:.|.|
  Rat   352 RKQYRKLAKSTLVLVLVFGVHYIVFICQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGE 416

  Fly   384 VRNALRHHISTWR---DTRTIQLNQNRRY----TTKSFSKGGGSPRAESMRPLTSYYGRGKRESC 441
            |:..::...:.|.   |.:........||    ||.:.|....|....|.| |.....:..:.:|
  Rat   417 VQAEVKKTWTRWNLSIDWKKAPPCGGHRYGSVLTTVTHSTSSQSQMGPSTR-LVLISSKPAKTAC 480

  Fly   442 VSSATTTTLVG 452
            ....:..||.|
  Rat   481 RQIDSHVTLPG 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	20/68 (29%)
		7tmB1_DH_R	126..394	CDD:320391	97/296 (33%)
		TM helix 1	128..153	CDD:320391	9/24 (38%)
		TM helix 2	162..184	CDD:320391	6/36 (17%)
		TM helix 3	197..224	CDD:320391	12/26 (46%)
		TM helix 4	236..256	CDD:320391	10/19 (53%)
		TM helix 5	279..308	CDD:320391	8/28 (29%)
		TM helix 6	322..349	CDD:320391	14/27 (52%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
Pth2r	NP_112351.2	HormR	60..133	CDD:214468	22/77 (29%)
		7tm_GPCRs	139..427	CDD:475119	97/297 (33%)
		TM helix 1	142..166	CDD:410628	9/24 (38%)
		TM helix 2	175..196	CDD:410628	6/20 (30%)
		TM helix 3	235..257	CDD:410628	8/21 (38%)
		TM helix 4	276..292	CDD:410628	9/15 (60%)
		TM helix 5	309..331	CDD:410628	7/21 (33%)
		TM helix 6	359..381	CDD:410628	9/21 (43%)
		TM helix 7	389..414	CDD:410628	8/24 (33%)